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Fermented black rice and blueberry with Lactobacillus plantarum MG4221 improve UVB-induced skin injury
Food and Agricultural Immunology ( IF 1.7 ) Pub Date : 2021-09-08 , DOI: 10.1080/09540105.2021.1967300
Seo Hyun Park 1, 2 , Jae Gon Kim 1, 3 , Young Ah Jang 4 , Al Borhan Bayazid 1 , Beong Ou Lim 1, 3
Affiliation  

ABSTRACT

Chronic ultraviolet (UV) exposure causes skin injury thorough the production of reactive oxygen species (ROS). Skin dryness, a characteristic of UV-induced injury, is closely related to skin barrier dysfunction. We investigated the effect of fermented black rice and blueberry with Lactobacillus plantarum (FBBBR) on UVB-induced skin injury. In vitro, FBBBR suppressed UVB-induced ROS generation, apoptosis, and metalloproteinase-9 expression, while increasing the expression of collagen type 1 alpha 1 (COL1A1) gene and natural moisturising factor-related genes such as filaggrin (FLG) and transglutaminase-1 (TGM-1). Oral administration of FBBBR increased serum catalase activity and decreased serum IgE levels, improved stratum corneum hydration and epidermal thickness and enhanced FLG, TGM-1, involucrin, and COL1A1 mRNA expression in dorsal skin in UVB-irradiated hairless mice. Therefore, we suggest that FBBBR can be used as a functional food with beneficial effects on skin hydration and skin barrier function.



中文翻译:

含有植物乳杆菌 MG4221 的发酵黑米和蓝莓改善 UVB 引起的皮肤损伤

摘要

慢性紫外线 (UV) 暴露会通过产生活性氧 (ROS) 导致皮肤损伤。皮肤干燥是紫外线损伤的一个特征,与皮肤屏障功能障碍密切相关。我们研究了发酵黑米和蓝莓与植物乳杆菌(FBBBR) 对 UVB 诱导的皮肤损伤的影响。在体外,FBBBR 抑制 UVB 诱导的 ROS 生成、细胞凋亡和金属蛋白酶-9 表达,同时增加胶原 1 型 α1 ( COL1A1 ) 基因和天然保湿因子相关基因如丝聚蛋白 ( FLG ) 和转谷氨酰胺酶-1 的表达。 ( TGM-1)。口服 FBBBR 可增加血清过氧化氢酶活性并降低血清 IgE 水平,改善角质层水合作用和表皮厚度,并增强UVB 照射的无毛小鼠背部皮肤中的FLGTGM-1、外皮蛋白和COL1A1 mRNA 表达。因此,我们建议 FBBBR 可用作功能性食品,对皮肤水合作用和皮肤屏障功能具有有益作用。

更新日期:2021-09-08
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