Progressive abnormality and loss of axons and neurons in the central nervous system (CNS) cause neurodegenerative diseases (NDs). Protein misfolding and its collection are the most important pathological features of NDs. Astrocytes are the most plentiful cells in the mammalian CNS (about 20–40% of the human brain) and have several central functions in the maintenance of the health and correct function of the CNS. Astrocytes have an essential role in the preservation of brain homeostasis, and it is not surprising that these multifunctional cells have been implicated in the onset and progression of several NDs. Thus, they become an exciting target for the study of NDs. Over almost 15 years, it was revealed that curcumin has several therapeutic effects in a wide variety of diseases’ treatment. Curcumin is a valuable ingredient present in turmeric spice and has several essential roles, including those which are anticarcinogenic, hepatoprotective, thrombosuppressive, cardioprotective, anti-arthritic, anti-inflammatory, antioxidant, chemopreventive, chemotherapeutic, and anti-infectious. Furthermore, curcumin can suppress inflammation; promote angiogenesis; and treat diabetes, pulmonary problems, and neurological dysfunction. Here, we review the effects of curcumin on astrocytes in NDs, with a focus on Alzheimer’s disease, Parkinson’s disease, multiple scleroses, Huntington’s disease, and amyotrophic lateral sclerosis.
Neuroimmunomodulation

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姜黄素对神经退行性疾病星形胶质细胞的功能作用

中枢神经系统 (CNS) 中轴突和神经元的进行性异常和丧失会导致神经退行性疾病 (NDs)。蛋白质错误折叠及其收集是 ND 最重要的病理特征。星形胶质细胞是哺乳动物中枢神经系统中最丰富的细胞（约占人脑的 20-40%），在维持中枢神经系统的健康和正常功能方面具有多种核心功能。星形胶质细胞在维持脑内稳态方面具有重要作用，这些多功能细胞与几种 ND 的发生和进展有关也就不足为奇了。因此，它们成为研究 ND 的一个令人兴奋的目标。近 15 年来，人们发现姜黄素在多种疾病的治疗中具有多种治疗效果。姜黄素是姜黄香料中的一种有价值的成分，具有多种重要作用，包括抗癌、保肝、抑制血栓、保护心脏、抗关节炎、抗炎、抗氧化、化学预防、化学治疗和抗感染。此外，姜黄素可以抑制炎症；促进血管生成；治疗糖尿病、肺部问题和神经功能障碍。在这里，我们回顾了姜黄素对 ND 星形胶质细胞的影响，重点关注阿尔茨海默病、帕金森病、多发性硬化症、亨廷顿病和肌萎缩侧索硬化症。和抗感染。此外，姜黄素可以抑制炎症；促进血管生成；治疗糖尿病、肺部问题和神经功能障碍。在这里，我们回顾了姜黄素对 ND 星形胶质细胞的影响，重点关注阿尔茨海默病、帕金森病、多发性硬化症、亨廷顿病和肌萎缩侧索硬化症。和抗感染。此外，姜黄素可以抑制炎症；促进血管生成；治疗糖尿病、肺部问题和神经功能障碍。在这里，我们回顾了姜黄素对 ND 星形胶质细胞的影响，重点关注阿尔茨海默病、帕金森病、多发性硬化症、亨廷顿病和肌萎缩侧索硬化症。
神经免疫调节