Alzheimer’s disease (AD) is a disease in cognitive regions in the human brain. Also the detection of AD in the early stage is too important. In this regard, a surface plasmon resonance (SPR) biosensor which comprises prism-silver/gold-SiO2 is proposed to detect of AD with high sensitivity. The properties of the AD sensor are numerically investigated with finite-difference time domain (FDTD) with different structural parameters. For this purpose, the effect of the incident beam waist, structural parameters, prism materials, and the temperature at 632 nm are then inspected to improve the structural parameters of the AD biosensor including the sensitivity and figure of merit (FOM). Our numerical calculations indicate that the proposed AD biosensor is able to operate with ultra-high sensitivity with maximum FOM of 31 and sensitivity of 1200 nm/refractive index unit (RIU) for small change of \(\Delta n\)= 0.4, in the refractive index of analyte. We believe that the proposed AD biosensor may be used as a potential platform for AD detection in earlier stages.

阿尔茨海默病 (AD) 是一种人类大脑认知区域的疾病。此外，早期AD的检测也太重要了。在这方面，提出了一种包含棱镜-银/金-SiO2 的表面等离子体共振 (SPR) 生物传感器来高灵敏度地检测 AD。AD 传感器的特性通过具有不同结构参数的有限差分时域 (FDTD) 进行数值研究。为此，然后检查入射束腰、结构参数、棱镜材料和 632 nm 温度的影响，以改善 AD 生物传感器的结构参数，包括灵敏度和品质因数 (FOM)。\(\Delta n\) = 0.4，在分析物的折射率中。我们相信所提出的 AD 生物传感器可用作早期 AD 检测的潜在平台。