Chemodynamic therapy (CDT) is an emerging tumour-specific therapeutic technology. However, the relatively insufficient catalytic activity of CDT agents in the tumour microenvironment (TME) limits their biomedical application. In addition, severe hypoxia and glutathione (GSH) overexpression in the TME greatly limit the antitumour efficiency of monotherapy. Herein, a cancer cell membrane-camouflaged and ultrasmall CeO₂-decorated MnO₂ (mMC) composite is developed for amplified CDT, photodynamic therapy (PDT) and photothermal therapy (PTT). Due to the homotypic targeting ability of cancer cell membranes, mMC nanoparticles preferentially accumulate in tumour tissue. In the TME, CeO₂ acts as a highly efficient CDT agent to convert endogenous H₂O₂ to toxic reactive oxygen species (ROS) for killing cancer cells. Meanwhile, MnO₂ irradiated with near-infrared (NIR) light displays prominent hyperthermia and ROS generation performance to perform PTT and PDT. Moreover, MnO₂ can produce oxygen to ameliorate hypoxia and deplete GSH to relieve the antioxidant capability of tumours, which is beneficial to the simultaneous augmentation of PDT and CDT. Most importantly, the catalytic activity of CeO₂ was greatly improved by hyperthermia. Consequently, a significantly enhanced therapeutic efficiency was obtained by the above multiple synergistic effects. This work provides a proof of concept for amplified tumour therapy by synchronously self-supplying oxygen, consuming GSH, and enhancing catalytic activity.

化学动力学疗法（CDT）是一种新兴的肿瘤特异性治疗技术。然而，CDT剂在肿瘤微环境（TME）中的催化活性相对不足，限制了它们的生物医学应用。此外，TME 中严重缺氧和谷胱甘肽 (GSH) 过度表达极大地限制了单药治疗的抗肿瘤效率。在此，开发了一种癌细胞膜伪装和超小 CeO ₂装饰的 MnO ₂ (mMC) 复合材料，用于放大 CDT、光动力疗法 (PDT) 和光热疗法 (PTT)。由于癌细胞膜的同型靶向能力，mMC纳米颗粒优先在肿瘤组织中积累。在 TME 中，CeO ₂作为高效的 CDT 试剂将内源性 H ₂转化为O ₂用于杀死癌细胞的有毒活性氧 (ROS)。同时，用近红外 (NIR) 光照射的MnO ₂显示出显着的热疗和 ROS 生成性能，以执行 PTT 和 PDT。此外，MnO ₂可以产生氧气改善缺氧状况并消耗GSH以减轻肿瘤的抗氧化能力，这有利于PDT和CDT的同时增强。最重要的是，CeO ₂的催化活性通过热疗得到了很大的改善。因此，通过上述多重协同作用获得了显着提高的治疗效率。这项工作通过同步自供氧、消耗谷胱甘肽和增强催化活性为放大肿瘤治疗提供了概念证明。