The increasing use of substances with endocrine disruptive properties (EDs) not only impacts aquatic organisms but can also have a direct negative effect on human health. In this comprehensive worldwide review, we collected ecotoxicology and concentration data observed in surface water for 53 high-potency EDs and performed a risk assessment. The compounds were selected from the EU watchlist of priority substances, expanded with new compounds of emerging concern (total 41), where quantifiable data were available for the past three years (2018–2020). The risk quotients ranged from <0.01 for 22 substances to 1974 for tamoxifen. The frequency of samples in which the predicted no-effect concentrations were exceeded also varied, from 1.8% to 92.7%. By using the comprehensive multi-parameter risk assessment in our study, the most current to date, we determined that tamoxifen, imidacloprid, clothianidin, four bisphenols (BPA, BPF, BPS, and BPAF), PFOA, amoxicillin, and three steroid hormones (estriol, estrone, and cyproterone) pose significant risks in the environment. Comparing two structurally very similar bisphenols, BPA and BPB, suggested that the risk from BPB is currently underestimated by at least four orders of magnitude due to the lack of ecotoxicological data availability. The methodological limitations encountered suggest that a standardized methodology for data selection and assessment is necessary, highlighting the fact that some substances are currently under-represented in the field of ecotoxicological research. A new prioritization system is therefore presented, which provides a potential basis for new substances to be included in environmental monitoring lists.

越来越多地使用具有内分泌干扰特性 (ED) 的物质，不仅会影响水生生物，还会对人类健康产生直接的负面影响。在这项全面的全球审查​​中，我们收集了在地表水中观察到的 53 种高效 ED 的生态毒理学和浓度数据，并进行了风险评估。这些化合物是从欧盟优先物质观察名单中挑选出来的，并增加了新出现的关注化合物（共 41 种），其中可获取过去三年（2018-2020 年）的量化数据。风险商的范围从 22 种物质的 <0.01 到他莫昔芬的 1974 年。超过预测的无影响浓度的样本频率也有所不同，从 1.8% 到 92.7%。通过在我们的研究中使用全面的多参数风险评估，这是迄今为止最新的，我们确定他莫昔芬、吡虫啉、噻虫胺、四种双酚（BPA、BPF、BPS 和 BPAF）、PFOA、阿莫西林和三种类固醇激素（雌三醇、雌酮和环丙孕酮）对环境构成重大风险。比较两种结构非常相似的双酚，BPA 和 BPB，表明由于缺乏生态毒理学数据，目前 BPB 的风险被低估了至少四个数量级。遇到的方法学限制表明，数据选择和评估的标准化方法是必要的，突出了一些物质目前在生态毒理学研究领域的代表性不足的事实。因此提出了一个新的优先系统，它为将新物质纳入环境监测清单提供了潜在的基础。