Endogenous peptides and structurally similar bacterial heat-stable enterotoxins (ST) bind guanylate cyclase-C (GC-C), resulting in fluid homeostasis or diarrhea, respectively. In this issue of Cell Host & Microbe, Carey et al., show how bats have evolutionarily maintained homeostatic signaling while avoiding pathogenic effects of ST.

中文翻译：

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改变肠道信号的锁定

内源性肽和结构相似的细菌热稳定性肠毒素 (ST) 结合鸟苷酸环化酶-C (GC-C)，分别导致液体稳态或腹泻。在本期Cell Host & Microbe中，Carey 等人展示了蝙蝠如何在进化上维持稳态信号，同时避免 ST 的致病作用。