A novel fluorescent probe for the detection of sulfur dioxide derivatives and its application in biological imaging,New Journal of Chemistry

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A novel fluorescent probe for the detection of sulfur dioxide derivatives and its application in biological imaging
New Journal of Chemistry ( IF 2.7 ) Pub Date : 2021-08-13 , DOI: 10.1039/d1nj03184h
Qing-Qing Yang ₁ , Qin-Qin Tian ₁ , Nan Ji ₁ , Xiao-Hong Duan ₂ , Xiao-Hong Zhu ₃ , Yan-Li Zhang ₂ , Wei He ₁

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An abnormal level of SO₂ is closely related to many diseases. Therefore, developing an effective method for the detection of SO₂ in biological environments has important physiological and pathological significance. In this work, a new fluorescent probe (CA-SO₂) was designed and synthesized for efficiently and specifically detecting SO₂ derivatives through nucleophilic addition reaction. The novel fluorescent probe (CA-SO₂) showed high selectivity, fast response time (within 50 s), and low detection limit (LOD = 75 nM). Furthermore, after adding SO₂ derivatives to the probe solution, the color of the solution changes from orange to colorless, which allows “naked eye” detection for SO₂. Moreover, the probe has a large Stokes shift (129 nm) and excellent biocompatibility. The probe has been successfully applied to the detection of SO₂ derivatives in living cells and zebrafish.

中文翻译：

一种用于检测二氧化硫衍生物的新型荧光探针及其在生物成像中的应用

SO ₂的异常水平与许多疾病密切相关。因此，开发一种检测生物环境中SO ₂的有效方法具有重要的生理和病理意义。在这项工作中，设计并合成了一种新的荧光探针（CA-SO ₂），用于通过亲核加成反应高效、特异性地检测 SO ₂衍生物。新型荧光探针（CA-SO ₂）显示出高选择性、快速响应时间（50 秒内）和低检测限（LOD = 75 nM）。此外，加入 SO _{2 后}探针溶液的衍生物，溶液的颜色从橙色变为无色，这使得 SO _{2 的}“肉眼”检测成为可能。此外，该探针具有较大的斯托克斯位移 (129 nm) 和出色的生物相容性。该探针已成功应用于活细胞和斑马鱼中SO ₂衍生物的检测。

更新日期：2021-09-08

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