Journal of Geriatric Psychiatry and Neurology ( IF 2.9 ) Pub Date : 2021-09-08 , DOI: 10.1177/08919887211044747 Brian G Collin 1 , Dheeraj Raju 2 , Steven Katsikas 1
Objective:
The current study assessed the effects of statin and CoQ10 supplement use on changes in cognitive functioning in the Wisconsin Registry for Alzheimer’s Prevention study.
Methods:
1,573 subjects were administered medical histories, the Mini-Mental State Examination (MMSE), Rey Auditory Verbal Learning Test (RAVLT), Wechsler Memory Scale, Logical Memory subtest, and the Trail Making Test, Parts A (TMT-A) and B (TMT-B) 3-4 times over 5-10 years.
Results:
Linear mixed models did not yield significant effects for statin or CoQ10 supplement use on changes in mental status, learning and memory, psychomotor speed, and cognitive flexibility.
Conclusions:
Statin and/or CoQ10 supplement use was not associated with neuropsychological test performance in the Wisconsin Registry for Alzheimer’s Prevention study.
中文翻译:
他汀类药物、辅酶 Q10 补充剂的使用和认知功能
客观的:
目前的研究评估了威斯康星州阿尔茨海默病预防登记处研究中他汀类药物和辅酶 Q 10补充剂的使用对认知功能变化的影响。
方法:
1,573 名受试者接受了病史、简易精神状态检查 (MMSE)、雷伊听觉言语学习测试 (RAVLT)、韦克斯勒记忆量表、逻辑记忆分项测试以及轨迹制作测试 A 部分 (TMT-A) 和 B 部分( TMT-B) 5-10 年内 3-4 次。
结果:
线性混合模型并未对他汀类药物或 CoQ 10补充剂的使用对精神状态、学习和记忆、精神运动速度和认知灵活性的变化产生显着影响。
结论:
在威斯康星州阿尔茨海默病预防登记研究中,他汀类药物和/或 CoQ 10补充剂的使用与神经心理学测试表现无关。