Oxidative Nucleophilic Functionalization of Nitrobenzene and 3-Nitroacetophenones with N−H Bonds,ChemistrySelect

当前位置： X-MOL 学术 › ChemistrySelect › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Oxidative Nucleophilic Functionalization of Nitrobenzene and 3-Nitroacetophenones with N−H Bonds
ChemistrySelect ( IF 1.9 ) Pub Date : 2021-09-08 , DOI: 10.1002/slct.202102169
Duy T. M. Chung _{1,

2} , Phuc Q. Le _{1,

2} , Huy X. Le _{1,

2} , Tien V. Huynh _{1,

2} , Anh N. Q. Phan _{1,

2} , Tung T. Nguyen _{1,

2} , Nam T. S. Phan _{1,

2}

Affiliation

Nitroarenes are versatile intermediate, thus found ubiquitous uses in synthesis of bio-related molecules and functional materials. Herein we develop methods for synthesis of substituted nitroarenes benefited from oxidative nucleophilic amination of C−H bonds para to the nitro functionality. Simple base NaOH was used to mediate the coupling of N−H heterocycles and nitrobenzene. Meanwhile, 5-nitro-1-aryl-1H-indazoles were isolated from copper-mediated annulation of 3-nitroaryl methyl ketones and arylhydrazines.

中文翻译：

具有 NH 键的硝基苯和 3-硝基苯乙酮的氧化亲核官能化

硝基芳烃是一种多功能中间体，因此在生物相关分子和功能材料的合成中广泛使用。在这里，我们开发了合成取代硝基芳烃的方法，这些方法受益于硝基官能团对位的 CH 键的氧化亲核胺化。简单的碱 NaOH 用于介导 NH 杂环和硝基苯的偶联。同时，从铜介导的 3-硝基芳基甲基酮和芳基肼的环化中分离出5-硝基-1-芳基-1 H-吲唑。

更新日期：2021-09-08

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11