Front Cover: Forward Chemical Genetic Screen for Oxygen-Dependent Cytotoxins Uncovers New Covalent Fragments that Target GPX4 (ChemBioChem 1/2022),ChemBioChem

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Front Cover: Forward Chemical Genetic Screen for Oxygen-Dependent Cytotoxins Uncovers New Covalent Fragments that Target GPX4 (ChemBioChem 1/2022)
ChemBioChem ( IF 2.6 ) Pub Date : 2021-09-07 , DOI: 10.1002/cbic.202100473
Marie B. Cordon ₁ , Kristian M. Jacobsen ₁ , Cecilie S. Nielsen ₁ , Per Hjerrild ₁ , Thomas B. Poulsen ₁

Affiliation

Oxygen is a central player in most aspects of life – without it, many life-giving processes will drag to a halt. Remarkably, some cell death mechanisms also require the presence of oxygen. In their study, Cordon et al. show how oxygen-deprivation impedes the execution of ferroptosis in cancer cells. Ferroptosis is an oxidative cell death process that ultimately leads to oxidation and destruction of lipid membranes. The findings underscore the importance of understanding the role of oxygen when developing anticancer treatments. The graphic was created with assistance from Lise Balsby and Astrid Friis Reitzel (Aarhus University). More information can be found in the Full Paper by T. B. Poulsen et al.

中文翻译：

封面：氧依赖性细胞毒素的前向化学遗传筛选揭示了靶向 GPX4 的新共价片段 (ChemBioChem 1/2022)

氧气是生活中大多数方面的核心参与者——没有它，许多赋予生命的过程将陷入停顿。值得注意的是，一些细胞死亡机制也需要氧气的存在。在他们的研究中，Cordon 等人。展示缺氧如何阻碍癌细胞中铁死亡的执行。铁死亡是一种氧化性细胞死亡过程，最终导致脂质膜的氧化和破坏。这些发现强调了在开发抗癌治疗时了解氧气的作用的重要性。该图形是在 Lise Balsby 和 Astrid Friis Reitzel（奥胡斯大学）的协助下创建的。更多信息可以在 T. B. Poulsen 等人的全文中找到。

更新日期：2021-09-07

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