Extracellular Matrix-Mimetic Hydrogels for Treating Neural Tissue Injury: A Focus on Fibrin, Hyaluronic Acid, and Elastin-Like Polypeptide Hydrogels,Advanced Healthcare Materials

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Extracellular Matrix-Mimetic Hydrogels for Treating Neural Tissue Injury: A Focus on Fibrin, Hyaluronic Acid, and Elastin-Like Polypeptide Hydrogels
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2021-09-08 , DOI: 10.1002/adhm.202101329
Derek W Nelson ₁ , Ryan J Gilbert ₁

Affiliation

Neurological and functional recovery is limited following central nervous system injury and severe injury to the peripheral nervous system. Extracellular matrix (ECM)-mimetic hydrogels are of particular interest as regenerative scaffolds for the injured nervous system as they provide 3D bioactive interfaces that modulate cellular response to the injury environment and provide naturally degradable scaffolding for effective tissue remodeling. In this review, three unique ECM-mimetic hydrogels used in models of neural injury are reviewed: fibrin hydrogels, which rely on a naturally occurring enzymatic gelation, hyaluronic acid hydrogels, which require chemical modification prior to chemical crosslinking, and elastin-like polypeptide (ELP) hydrogels, which exhibit a temperature-sensitive gelation. The hydrogels are reviewed by summarizing their unique biological properties, their use as drug depots, and their combination with other biomaterials, such as electrospun fibers and nanoparticles. This review is the first to focus on these three ECM-mimetic hydrogels for their use in neural tissue engineering. Additionally, this is the first review to summarize the use of ELP hydrogels for nervous system applications. ECM-mimetic hydrogels have shown great promise in preclinical models of neural injury and future advancements in their design and use can likely lead to viable treatments for patients with neural injury.

中文翻译：

用于治疗神经组织损伤的细胞外基质模拟水凝胶：聚焦纤维蛋白、透明质酸和弹性蛋白样多肽水凝胶

中枢神经系统损伤和周围神经系统严重损伤后，神经和功能恢复受到限制。细胞外基质（ECM）模拟水凝胶作为受损神经系统的再生支架特别令人感兴趣，因为它们提供了 3D 生物活性界面，可调节细胞对损伤环境的反应，并为有效的组织重塑提供自然可降解的支架。在这篇综述中，综述了神经损伤模型中使用的三种独特的 ECM 模拟水凝胶：纤维蛋白水凝胶，依赖于自然发生的酶凝胶化，透明质酸水凝胶，在化学交联之前需要化学修饰，以及弹性蛋白样多肽。 ELP）水凝胶，表现出温度敏感性凝胶化。通过总结水凝胶独特的生物特性、它们作为药物储存库的用途以及它们与其他生物材料（例如电纺纤维和纳米颗粒）的组合来对水凝胶进行审查。本综述首次重点关注这三种 ECM 模拟水凝胶在神经组织工程中的应用。此外，这是第一次总结 ELP 水凝胶在神经系统应用中的应用。 ECM 模拟水凝胶在神经损伤的临床前模型中显示出巨大的前景，其设计和使用的未来进步可能会为神经损伤患者带来可行的治疗方法。

更新日期：2021-11-17

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