Pituitary growth hormone (GH)-secreting adenomas (GH-PAs) cause mass effects and dysregulated hypersecretion of GH. However, somatic mutation burden is low in PAs. While progress has been made in identifying the epigenetic changes involved in GH-PA initiation, the precise details of its tumorigenesis in GH-PA patients remains to be elucidated. As N ⁶-methyladenosine (m ⁶A) has been shown to often play a critical role in various tumors, it represents a possible initiation point for the tumorigenesis of pituitary adenomas. However, the role of RNA methylation in GH adenomas remains unclear.

中文翻译：

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METTL3介导的RNA m6A高甲基化促进垂体生长激素腺瘤的肿瘤发生和GH分泌

垂体生长激素 (GH) 分泌腺瘤 (GH-PAs) 会导致质量效应和 GH 失调的过度分泌。然而，PA 的体细胞突变负担较低。虽然在确定 GH-PA 起始所涉及的表观遗传变化方面取得了进展，但其在 GH-PA 患者中肿瘤发生的确切细节仍有待阐明。由于 N ⁶ -甲基腺苷 (m ⁶ A) 已被证明经常在各种肿瘤中发挥关键作用，因此它代表了垂体腺瘤肿瘤发生的可能起始点。然而，RNA 甲基化在 GH 腺瘤中的作用仍不清楚。