Strong, Multifaceted Guanidinium-Based Adhesion of Bioorganic Nanoparticles to Wet Biological Tissue,JACS Au

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Strong, Multifaceted Guanidinium-Based Adhesion of Bioorganic Nanoparticles to Wet Biological Tissue
JACS Au ( IF 8.5 ) Pub Date : 2021-09-08 , DOI: 10.1021/jacsau.1c00193
Lam Tan Hao _{1,

2} , Sohee Park ₃ , Seunghwan Choy ₄ , Young-Min Kim ₅ , Seung-Woo Lee _{5,

6} , Yong Sik Ok ₇ , Jun Mo Koo ₁ , Sung Yeon Hwang _{1,

2} , Dong Soo Hwang ₃ , Jeyoung Park _{1,

2} , Dongyeop X Oh _{1,

2}

Affiliation

Gluing dynamic, wet biological tissue is important in injury treatment yet difficult to achieve. Polymeric adhesives are inconvenient to handle due to rapid cross-linking and can raise biocompatibility concerns. Inorganic nanoparticles adhere weakly to wet surfaces. Herein, an aqueous suspension of guanidinium-functionalized chitin nanoparticles as a biomedical adhesive with biocompatible, hemostatic, and antibacterial properties is developed. It glues porcine skin up to 3000-fold more strongly (30 kPa) than inorganic nanoparticles at the same concentration and adheres at neutral pH, which is unachievable with mussel-inspired adhesives alone. The glue exhibits an instant adhesion (2 min) to fully wet surfaces, and the glued assembly endures one-week underwater immersion. The suspension is lowly viscous and stable, hence sprayable and convenient to store. A nanomechanic study reveals that guanidinium moieties are chaotropic, creating strong, multifaceted noncovalent bonds with proteins: salt bridges comprising ionic attraction and bidentate hydrogen bonding with acidic moieties, cation−π interactions with aromatic moieties, and hydrophobic interactions. The adhesion mechanism provides a blueprint for advanced tissue adhesives.

中文翻译：

生物有机纳米颗粒对湿生物组织的强、多方面的胍基粘附

粘合动态、潮湿的生物组织在损伤治疗中很重要，但很难实现。由于快速交联，聚合物粘合剂不方便处理，并且会引起生物相容性问题。无机纳米粒子较弱地粘附在湿表面上。在此，开发了胍基功能化几丁质纳米粒子的水性悬浮液，作为具有生物相容性、止血和抗菌性能的生物医学粘合剂。与相同浓度的无机纳米粒子相比，它对猪皮的粘合力高达 3000 倍 (30 kPa)，并在中性 pH 下粘合，这是仅使用受贻贝启发的粘合剂无法实现的。胶水对完全湿润的表面具有瞬间粘合力（2 分钟），胶合后的组件可在水下浸泡一周。悬浮液粘度低且稳定，因此可喷涂且便于储存。一项纳米力学研究表明，胍基部分是离液的，与蛋白质形成强的、多方面的非共价键：盐桥包括离子吸引力和与酸性部分的双齿氢键、与芳香部分的阳离子-π 相互作用和疏水性相互作用。粘附机制为高级组织粘合剂提供了蓝图。

更新日期：2021-09-27

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