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Glycopeptide-Conjugated Aggregation-Induced Emission Luminogen: A pH-Responsive Fluorescence Probe with Tunable Self-Assembly Morphologies for Cell Imaging
The Journal of Physical Chemistry B ( IF 2.8 ) Pub Date : 2021-09-08 , DOI: 10.1021/acs.jpcb.1c06443 Fangling Zhang 1, 2 , Yangqing He 1 , Xin Jin 2 , Song Xiang 3 , Hai-Tao Feng 3 , Li-Li Li 2
The Journal of Physical Chemistry B ( IF 2.8 ) Pub Date : 2021-09-08 , DOI: 10.1021/acs.jpcb.1c06443 Fangling Zhang 1, 2 , Yangqing He 1 , Xin Jin 2 , Song Xiang 3 , Hai-Tao Feng 3 , Li-Li Li 2
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pH values play an important role in various cell biological processes. Abnormal pH values in living systems are frequently associated with the development of diseases such as cancers, infection, and other diseases. Real-time monitoring of the changes of pH values in vivo will give us the significant indication for these diseases’ progression. Within those pH-sensitive imaging probes, aggregation-induced emission (AIE) molecules exhibit great potential in aqueous imaging environment due to their high fluorescence quantum yield and stability. However, the modulation of the AIE probe with pH sensitivity and light-up property face challenges. Here, we introduced a new glycopeptide-modified AIE probe (TGO) based on the optimized solid-phase peptide synthesis approach. The response to pH of the peptide: DDDD progression changed hydrophobicity and hydrophilicity, resulting in the change of the amphipathicity balance. When modulating the pH from 5.5 to 8.0, the adverse protonation of the peptide induced assembled nanostructure transformation from nanolamellae to nanomicelles. Meanwhile, the pH-induced charge change in peptides can greatly influence the microenvironment of the AIEgen, resulting in the increase of fluorescence intensity.
中文翻译：
糖肽共轭聚集诱导发光发光原：具有可调自组装形态的 pH 响应荧光探针，用于细胞成像
pH 值在各种细胞生物学过程中起着重要作用。生命系统中的异常 pH 值通常与癌症、感染和其他疾病等疾病的发展有关。实时监测体内pH 值的变化将为我们提供这些疾病进展的重要指示。在这些 pH 敏感成像探针中，聚集诱导发射 (AIE) 分子由于其高荧光量子产率和稳定性而在水性成像环境中表现出巨大的潜力。然而，具有 pH 敏感性和点亮特性的 AIE 探针的调制面临挑战。在这里，我们介绍了一种新的糖肽修饰的 AIE 探针（TGO) 基于优化的固相肽合成方法。肽对pH的反应：DDDD进展改变了疏水性和亲水性，导致两亲性平衡的变化。当将 pH 值从 5.5 调节到 8.0 时，肽的不利质子化诱导组装的纳米结构从纳米片层转变为纳米胶束。同时，肽中pH诱导的电荷变化会极大地影响AIEgen的微环境，导致荧光强度增加。
更新日期：2021-09-16
中文翻译：
糖肽共轭聚集诱导发光发光原：具有可调自组装形态的 pH 响应荧光探针，用于细胞成像
pH 值在各种细胞生物学过程中起着重要作用。生命系统中的异常 pH 值通常与癌症、感染和其他疾病等疾病的发展有关。实时监测体内pH 值的变化将为我们提供这些疾病进展的重要指示。在这些 pH 敏感成像探针中，聚集诱导发射 (AIE) 分子由于其高荧光量子产率和稳定性而在水性成像环境中表现出巨大的潜力。然而，具有 pH 敏感性和点亮特性的 AIE 探针的调制面临挑战。在这里，我们介绍了一种新的糖肽修饰的 AIE 探针（TGO) 基于优化的固相肽合成方法。肽对pH的反应：DDDD进展改变了疏水性和亲水性，导致两亲性平衡的变化。当将 pH 值从 5.5 调节到 8.0 时，肽的不利质子化诱导组装的纳米结构从纳米片层转变为纳米胶束。同时，肽中pH诱导的电荷变化会极大地影响AIEgen的微环境，导致荧光强度增加。
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