Direct Access to α,β-Unsaturated Ketones via Rh/MgCl2-Mediated Acylation of Vinylsilanes,The Journal of Organic Chemistry

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Direct Access to α,β-Unsaturated Ketones via Rh/MgCl2-Mediated Acylation of Vinylsilanes
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2021-09-07 , DOI: 10.1021/acs.joc.1c01205
Xue-Zu Deng ₁ , Zi-Yan Chen ₁ , Yang Song ₁ , Fei Xue ₂ , Motoki Yamane ₃ , Yan-Ni Yue ₁

Affiliation

We report herein the facile and practical construction of α,β-unsaturated ketones via rhodium-catalyzed direct acylation of vinylsilanes with readily available and abundant carboxylic acids. This protocol features access to a diverse array of synthetically useful functionalities with moderate to excellent yields. More importantly, the late-stage functionalization of pharmaceuticals was also realized with synthetically useful yield.

中文翻译：

通过 Rh/MgCl2 介导的乙烯基硅烷酰化直接获得 α,β-不饱和酮

我们在此报告了通过铑催化的乙烯基硅烷与易得且丰富的羧酸的直接酰化来构建 α,β-不饱和酮的简便实用的结构。该协议的特点是可以访问各种综合有用的功能，并具有中等至出色的产量。更重要的是，药物的后期功能化也以合成有用的产率实现。

更新日期：2021-09-17

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