Cannabis contains a multitude of different compounds. One of them, cannabidiol – a non-psychoactive substance – might counteract negative effects of Δ-9-Tetrahydrocannabinol on hippocampus-dependent memory impairment. The aim of the present study was to investigate the effect of vaping cannabidiol on verbal episodic memory in healthy young subjects. We used a double-blind, placebo-controlled, randomized crossover trial in 39 healthy young subjects. Participants received once a single dose of cannabidiol e-liquid (0.25 ml, 5% cannabidiol, 12.5 mg cannabidiol) and once placebo for vaping after learning 15 unrelated nouns. The primary outcome measure was the short delay verbal memory performance (number of correctly free recalled nouns) 20 min after learning. 34 participants (mean age: 22.26 [3.04]) completed all visits and entered analyses (17 received cannabidiol and 17 received placebo first). Cannabidiol enhanced verbal episodic memory performance (placebo: 7.03 [2.34]; cannabidiol 7.71 [2.48]; adjusted group difference 0.68, 95% CI 0.01 to 1.35; R_2β = .028, p = .048). Importantly, we did not detect medication effects on secondary outcome measures attention or working memory performance, suggesting that CBD has no negative impact on these basic cognitive functions. The results are in line with the idea that vaping cannabidiol interacts with the central endocannabinoid system and is capable to modulate memory processes, a phenomenon with possible therapeutic potential. Further studies are needed to investigate optimal dose-response and time-response relationships.

大麻含有多种不同的化合物。其中之一，大麻二酚 - 一种非精神活性物质 - 可能会抵消 Δ-9-四氢大麻酚对海马依赖性记忆障碍的负面影响。本研究的目的是调查吸食大麻二酚对健康年轻受试者的言语情景记忆的影响。我们在 39 名健康年轻受试者中使用了一项双盲、安慰剂对照、随机交叉试验。参与者在学习了 15 个不相关的名词后，接受了一次单剂量的大麻二酚电子烟液（0.25 毫升，5% 大麻二酚，12.5 毫克大麻二酚）和一次安慰剂用于电子烟。主要结果测量是学习后 20 分钟的短延迟语言记忆表现（正确自由回忆名词的数量）。34 名参与者（平均年龄：22.26 [3. 04]) 完成了所有访问并进行了分析（17 人首先接受了大麻二酚，17 人首先接受了安慰剂）。大麻二酚增强了言语情景记忆表现（安慰剂：7.03 [2.34]；大麻二酚 7.71 [2.48]；调整组差异 0.68，95% CI 0.01 至 1.35；R _2β =  .028 ，p = .048）。重要的是，我们没有检测到药物对次要结果指标注意力或工作记忆表现的影响，这表明 CBD 对这些基本认知功能没有负面影响。结果与电子烟与中枢内源性大麻素系统相互作用并能够调节记忆过程的想法一致，这种现象可能具有治疗潜力。需要进一步的研究来调查最佳剂量反应和时间反应关系。