A nanoparticle (NP) immersed in biological media rapidly forms a corona of adsorbed proteins, which later controls the eventual fate of the particle and the route through which adverse outcomes may occur. The composition and timescale for the formation of this corona are both highly dependent on both the NP and its environment. The deposition of proteins on the surface of the NP can be imitated by a process of random sequential adsorption, and, based on this model, we develop a rate-equation treatment for the formation of a corona represented by hard spheres on spherical and cylindrical NPs. We find that the geometry of the NP significantly alters the composition of the corona through a process independent of the rate constants assumed for adsorption and desorption of proteins, with the radius and shape of the NP both influencing the corona. We further investigate the roles of protein mobility on the surface of the NP and changes in the concentration of proteins.

浸入生物介质中的纳米颗粒 (NP) 迅速形成吸附蛋白的电晕，随后控制颗粒的最终命运以及可能发生不良后果的途径。该日冕形成的成分和时间尺度都高度依赖于 NP 及其环境。蛋白质在 NP 表面的沉积可以通过随机顺序吸附过程来模拟，并且基于该模型，我们开发了一种速率方程处理，用于在球形和圆柱形 NPs 上形成以硬球为代表的电晕. 我们发现 NP 的几何形状通过一个独立于蛋白质吸附和解吸假设的速率常数的过程显着改变了电晕的组成，NP 的半径和形状都影响电晕。