Background

In this study, we report clinical outcomes in COVID-19 infection in a large cohort of people with cystic fibrosis (pwCF) and compare these outcomes to a propensity score matched cohort of people without CF.

Methods

Analysis of a multicenter research network TriNETX was performed including patients more than 16 years of age diagnosed with COVID-19. Outcomes in COVID-19 positive pwCF were compared with a propensity-matched cohort of people without CF.

Results

A total of 507,810 patients with COVID-19 were included (422 patients, 0.08% with CF; 507,388 patients, 99.92% without CF. Mean age at COVID-19 diagnosis in CF cohort was 46.6 ± 19.3 years, with female predominance (n = 225, 53.32%). Majority of the participants were Caucasian (n = 309, 73.22%). In the crude, unmatched analysis, mortality, hospitalization, critical care need, mechanical ventilation, acute kidney injury and composite (combination of intubation and mortality) outcome at 30 days was higher in the pwCF. Following robust propensity matching, pwCF had higher hospitalization rate (RR 1.56, 95% CI 1.20–2.04), critical care need (RR 1.78, 95% CI 1.13–2.79), and acute renal injury (RR 1.60, 95% CI 1.07–2.39) as compared to patients without CF.

Conclusion

People with CF are at risk of poor outcomes with COVID-19.5.2% of these patients died within one month of COVID-19 diagnosis, and more than one in 10 patients required critical care. Therefore, the relatively young median age of cystic fibrosis patients, and lower prevalence of obesity do not protect these patients from severe disease contrary to prior reports.

中文翻译：

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囊性纤维化患者感染 SARS-CoV-2 的结果：一项多中心回顾性研究网络研究

背景

在这项研究中，我们报告了一大群囊性纤维化 (pwCF) 患者 COVID-19 感染的临床结果，并将这些结果与倾向评分匹配的非 CF 患者队列进行了比较。

方法

对多中心研究网络 TriNETX 进行了分析，其中包括 16 岁以上被诊断患有 COVID-19 的患者。将 COVID-19 阳性 pwCF 的结果与没有 CF 的人的倾向匹配队列进行了比较。

结果

共纳入 507,810 名 COVID-19 患者（422 名患者，0.08% 患有 CF；507,388 名患者，99.92% 未患有 CF。CF 队列中 COVID-19 诊断时的平均年龄为 46.6 ± 19.3 岁，女性占主导地位（n = 225, 53.32%)。大多数参与者是白种人 (n = 309, 73.22%)。在粗略的、不匹配的分析中，死亡率、住院率、重症监护需要、机械通气、急性肾损伤和复合（插管和死亡率的组合） ) pwCF 的 30 天结果更高。经过稳健的倾向匹配后，pwCF 具有更高的住院率（RR 1.56，95% CI 1.20-2.04）、重症监护需求（RR 1.78，95% CI 1.13-2.79）和急性与没有 CF 的患者相比，肾损伤（RR 1.60，95% CI 1.07–2.39）。

结论

CF 患者有 COVID-19.5.2% 的患者在 COVID-19 诊断后一个月内死亡的风险，超过十分之一的患者需要重症监护。因此，与先前的报道相反，囊性纤维化患者相对年轻的中位年龄和较低的肥胖患病率并不能保护这些患者免受严重疾病的侵害。