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Novel Approach to the Synthesis of 3-amino-4-arylpyridin-2(1H)-one Derivatives
Chemistry of Heterocyclic Compounds ( IF 1.4 ) Pub Date : 2021-09-07 , DOI: 10.1007/s10593-021-02980-w
Vladislav Yu Shuvalov 1 , Sergei А Chernenko 1 , Anton L Shatsauskas 1 , Anna L Samsonenko 2 , Maksim V Dmitriev 3 , Alexander S Fisyuk 1, 2
Affiliation  

The reaction of 4-arylidene-2-phenyloxazol-5(4H)-ones with enamines of ethyl acetoacetate gave 4-aryl-2-methyl-6-oxo-5-[(phenylcarbonyl)amino]-1,4,5,6-tetrahydropyridine-3-carboxylic acid esters, which, when heated with phosphorus oxychloride, were converted into esters of 7-aryl-5-methyl-2-phenyloxazolo[5,4-b]pyridine-6-carboxylic acids. Alkaline hydrolysis of these compounds gave 4-aryl-2-methyl-6-oxo-5-[(phenylcarbonyl)amino]-1,6-dihydropyridine-3-carboxylic acid esters.



中文翻译:


3-氨基-4-芳基吡啶-2(1H)-酮衍生物的合成新方法



4-亚芳基-2-苯基恶唑-5(4 H )-酮与乙酰乙酸乙酯的烯胺反应得到4-芳基-2-甲基-6-氧代-5-[(苯基羰基)氨基]-1,4,5 ,6-四氢吡啶-3-羧酸酯,当与三氯氧磷一起加热时,转化为7-芳基-5-甲基-2-苯基恶唑并[5,4- b ]吡啶-6-羧酸的酯。这些化合物的碱性水解得到4-芳基-2-甲基-6-氧代-5-[(苯基羰基)氨基]-1,6-二氢吡啶-3-羧酸酯。

更新日期:2021-09-08
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