Selenophenochromones Selectively Inhibit Human Lung Carcinoma Cells Growth,Chemistry of Heterocyclic Compounds

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Selenophenochromones Selectively Inhibit Human Lung Carcinoma Cells Growth
Chemistry of Heterocyclic Compounds ( IF 1.4 ) Pub Date : 2021-09-07 , DOI: 10.1007/s10593-021-02990-8
Jelena Vasiljeva ₁ , Ilona Domracheva ₁ , Pavel Arsenyan ₁

Affiliation

Synthetic procedures for the preparation of selenophenochromones by treating ethynyl chromones with selenium halides were elaborated. Methyl 3-bromo-2-(1-hydroxycyclohexyl)-9-oxo-9H-selenopheno[2,3-f]chromene-7-carboxylate exhibits high selective in vitro cytotoxic activity against human lung carcinoma cells A549 and H69 up to 1.2 μM.

中文翻译：

Selenophenochromones 选择性抑制人肺癌细胞生长

详细阐述了通过用卤化硒处理乙炔色酮来制备硒苯色酮的合成方法。Methyl 3-bromo-2-(1-hydroxycyclohexyl)-9-oxo-9 H - selenopheno[2,3 - f ] chromene -7-carboxylate对人肺癌细胞 A549 和 H69表现出高选择性的体外细胞毒活性1.2 微米。

更新日期：2021-09-08

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