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Improving SIRT1 by trehalose supplementation reduces oxidative stress, inflammation, and histopathological scores in the kidney of aged rats
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2021-09-08 , DOI: 10.1111/jfbc.13931 Faegheh Bahri 1 , Mohammad Khaksari 2 , Sajjadeh Movahedinia 3 , Bentolhoda Shafiei 1 , Mohammad Amin Rajizadeh 4 , Mahdieh Nazari-Robati 1
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2021-09-08 , DOI: 10.1111/jfbc.13931 Faegheh Bahri 1 , Mohammad Khaksari 2 , Sajjadeh Movahedinia 3 , Bentolhoda Shafiei 1 , Mohammad Amin Rajizadeh 4 , Mahdieh Nazari-Robati 1
Affiliation
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The aging process leads to progressive loss of kidney function. Sirtuin1 (SIRT1) exerts renoprotective effects by conferring resistance to cellular stresses. Trehalose potentially displayed various beneficial effects to promote health span. In this study, we investigated the effects of trehalose on renal SIRT1 and kidney function in senescent rats. Trehalose (2% w/v) was administrated in drinking water for 1 month to male aged rats (24 months). Then, the level of SIRT1 mRNA and protein, malondialdehyde, total antioxidant capacity, tumor necrosis factor α as well as parameters related to the function and histology of the kidneys were evaluated. Trehalose supplementation increased the level of SIRT1, whereas alleviated the level of oxidative stress, inflammation, and histopathology scores in senescent tissues. However, trehalose administration did not alter kidney function indices in old rats. Collectively, these findings suggested that trehalose was an effective intervention to ameliorate some aspects of age-associated injury in the old kidneys.
中文翻译：
通过补充海藻糖改善 SIRT1 可降低老年大鼠肾脏的氧化应激、炎症和组织病理学评分
衰老过程导致肾功能逐渐丧失。Sirtuin1 (SIRT1) 通过赋予对细胞应激的抵抗力来发挥肾脏保护作用。海藻糖可能显示出各种有益效果，以促进健康。在这项研究中，我们研究了海藻糖对衰老大鼠肾脏 SIRT1 和肾功能的影响。将海藻糖 (2% w/v) 在饮用水中给予雄性老年大鼠 (24 个月) 1 个月。然后，评估SIRT1 mRNA和蛋白质、丙二醛、总抗氧化能力、肿瘤坏死因子α以及与肾脏功能和组织学相关的参数。海藻糖补充剂增加了 SIRT1 的水平，同时减轻了衰老组织中氧化应激、炎症和组织病理学评分的水平。然而，海藻糖给药不会改变老年大鼠的肾功能指数。总的来说，这些发现表明海藻糖是一种有效的干预措施，可以改善老年肾脏中与年龄相关的损伤的某些方面。
更新日期：2021-10-06
中文翻译：
通过补充海藻糖改善 SIRT1 可降低老年大鼠肾脏的氧化应激、炎症和组织病理学评分
衰老过程导致肾功能逐渐丧失。Sirtuin1 (SIRT1) 通过赋予对细胞应激的抵抗力来发挥肾脏保护作用。海藻糖可能显示出各种有益效果，以促进健康。在这项研究中，我们研究了海藻糖对衰老大鼠肾脏 SIRT1 和肾功能的影响。将海藻糖 (2% w/v) 在饮用水中给予雄性老年大鼠 (24 个月) 1 个月。然后，评估SIRT1 mRNA和蛋白质、丙二醛、总抗氧化能力、肿瘤坏死因子α以及与肾脏功能和组织学相关的参数。海藻糖补充剂增加了 SIRT1 的水平，同时减轻了衰老组织中氧化应激、炎症和组织病理学评分的水平。然而，海藻糖给药不会改变老年大鼠的肾功能指数。总的来说，这些发现表明海藻糖是一种有效的干预措施，可以改善老年肾脏中与年龄相关的损伤的某些方面。
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