The kinetics of the oxidation reactions of APAP and Cafn by a Mn(IV)-oxidant, [Mn^IV₃(µ-O)₄(phen)₄(H₂O)₂]⁴⁺ (1) has been studied at room temperature. Under the acidic reaction condition ([H⁺] = 0.2–1.0 M), both APAP and Cafn exist in equilibrium with their conjugate acids APAPH⁺ and CafnH⁺ and each of the species acts as the potential reductants. Kinetic observations reveal that the observed rate constant, k_o, values increase with the increase in media acidity and the ionic strength, I. The second-order rate-constant values for oxidizing the protonated forms of the two reductants (APAPH⁺ and CafnH⁺) were evaluated to be 6.04 ± 0.29 and 0.18 ± 0.01 M⁻¹ s⁻¹, respectively. Overall, under acid media, Mn(IV)-complex efficiently oxidizes APAP to a mixture of benzoquinone and acetamide (or, to quinone oxime and acetic acid) and Cafn to 1,3,7-trimethyluric acid.

已在室温下研究了APAP和Cafn由 Mn(IV)氧化剂[Mn ^IV ₃ (µ-O) ₄ (phen) ₄ (H ₂ O) ₂ ] ⁴⁺ ( 1 )氧化反应的动力学温度。在酸性反应条件下（[H ⁺ ] = 0.2–1.0 M），APAP和Cafn与其共轭酸APAP H ⁺和Cafn H ⁺处于平衡状态，并且每种物质都充当潜在的还原剂。动力学观察表明，观察到的速率常数，k _o值随着介质酸度和离子强度I 的增加而增加。氧化两种还原剂（APAP H ⁺和Cafn H ⁺）的质子化形式的二级速率常数值分别评估为6.04 ± 0.29 和0.18 ± 0.01 M ^-1  s ^-1。总体而言，在酸性介质下，Mn(IV)-复合物有效地将APAP氧化为苯醌和乙酰胺的混合物（或醌肟和乙酸），并将Cafn 氧化为1,3,7-三甲基尿酸。