Conductive dual hydrogen bonding hydrogels for the electrical stimulation of infected chronic wounds,Journal of Materials Chemistry B

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Conductive dual hydrogen bonding hydrogels for the electrical stimulation of infected chronic wounds
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2021-08-20 , DOI: 10.1039/d1tb01432c
Ye Wu ₁ , Yuhui Lu ₂ , Can Wu ₂ , Jiali Chen ₁ , Ning Ning ₁ , Zeyu Yang ₃ , Yi Guo ₃ , Jieyu Zhang ₂ , Xuefeng Hu ₂ , Yunbing Wang ₂

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Electrical stimulation (ES) via rigid electrodes near the wound is one of the promising approaches for chronic wound treatment, but it is unable to stimulate the whole wound area and treat infected wounds. In this study, a tough conductive hydrogel was prepared by the copolymerization of N-acryloyl glycinamide (NAGA) with quaternized chitosan-g-polyaniline (QCSP). The hydrogel showed a similar conductivity to the human skin and robust mechanical properties due to the dual hydrogen bonding motifs. The grafted polyaniline segments and functionalized quaternary ammonium groups showed intense antimicrobial activity against Pseudomonas aeruginosa and Staphylococcus aureus biofilms. The in vivo assay in diabetic rats proves that the ES via the conductive hydrogel was more effective in promoting the healing of infected wounds than the conventional ES via rigid electrodes. Due to the excellent flexibility and antibacterial properties, this conductive hydrogel shows great promise for infected chronic wound treatment.

中文翻译：

用于电刺激感染慢性伤口的导电双氢键水凝胶

通过伤口附近的刚性电极进行电刺激 (ES)是治疗慢性伤口的有希望的方法之一，但它无法刺激整个伤口区域并治疗感染的伤口。在这项研究中，通过N-丙烯酰甘氨酰胺 (NAGA) 与季铵化壳聚糖-g-聚苯胺 (QCSP) 的共聚制备了一种坚韧的导电水凝胶。由于双氢键基序，水凝胶表现出与人体皮肤相似的导电性和强大的机械性能。接枝的聚苯胺链段和功能化的季铵基团对铜绿假单胞菌和金黄色葡萄球菌生物膜表现出强烈的抗菌活性。体内_在糖尿病大鼠中进行的试验证明，通过导电水凝胶的 ES 在促进感染伤口愈合方面比通过刚性电极的传统 ES 更有效。由于具有出色的柔韧性和抗菌性能，这种导电水凝胶在感染的慢性伤口治疗中显示出巨大的希望。

更新日期：2021-09-08

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