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Fe3O4–Au–polydopamine hybrid microcapsules with photothermal–photodynamic synergistic anti-bacterial performance
CrystEngComm ( IF 2.6 ) Pub Date : 2021-08-24 , DOI: 10.1039/d1ce00926e Qunling Fang 1 , Kezhu Xu 1 , Qingshan Xiong 1 , Yunqi Xu 2 , Ailing Hui 1 , Shouhu Xuan 2
CrystEngComm ( IF 2.6 ) Pub Date : 2021-08-24 , DOI: 10.1039/d1ce00926e Qunling Fang 1 , Kezhu Xu 1 , Qingshan Xiong 1 , Yunqi Xu 2 , Ailing Hui 1 , Shouhu Xuan 2
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Infectious diseases associated with drug-resistant bacteria increasingly threaten public health. Effective antibacterial nanoplatforms are of special importance for treating bacterial infections. In this work, a novel magnetic Fe3O4–Au–PDA hybrid microcapsule with both photothermal (PTT) and photodynamic (PDT) anti-bacterial functions was developed. First, the Fe3O4@Au/PDA core/shell microspheres with hollow nature were obtained by a simple in situ redox–oxidize polymerization method. Then, they were etched in acid to improve the hollow interior and porous shell. Finally, the tetracarboxyzinc phthalocyanine (ZnPc) was used as the photosensitizer to be loaded into the above Fe3O4–Au–PDA hybrid microcapsule. Owing to the dual-mode photothermal Au–PDA hybrid shell and the ZnPc photosensitizer, the final Fe3O4–Au–PDA/ZnPc hybrid microcapsule serves as a wonderful photothermal/photodynamic (PTT/PDT) synergistic therapy agent. The experimental results show that the Fe3O4–Au–PDA/ZnPc microcapsule possesses excellent photothermal sterilization effect (808 nm laser irradiation) against Escherichia coli, and the experimental results further demonstrate good photodynamic behavior under Xenon lamp irradiation. The product exhibits much higher antibacterial performance by combining the PTT/PDT treatment, which demonstrates that this work provides a novel dual-mode phototheranostic nano-agent for an effective treatment of bacterial infections.
中文翻译：
具有光热-光动力协同抗菌性能的Fe3O4-Au-聚多巴胺杂化微胶囊
与耐药菌相关的传染病日益威胁着公众健康。有效的抗菌纳米平台对于治疗细菌感染特别重要。在这项工作中，开发了一种具有光热 (PTT) 和光动力 (PDT) 抗菌功能的新型磁性 Fe 3 O 4 -Au-PDA 混合微胶囊。首先，通过简单的原位氧化还原-氧化聚合方法获得了具有中空性质的 Fe 3 O 4 @Au/PDA 核/壳微球。然后，它们在酸中蚀刻以改善中空内部和多孔外壳。最后，以四羧基锌酞菁（ZnPc）为光敏剂负载到上述Fe 3 O中4 -Au-PDA 混合微胶囊。由于双模式光热 Au-PDA 杂化壳和 ZnPc 光敏剂，最终的 Fe 3 O 4 -Au-PDA/ZnPc 杂化微胶囊可用作出色的光热/光动力 (PTT/PDT) 协同治疗剂。实验结果表明，Fe 3 O 4 -Au-PDA/ZnPc 微胶囊对大肠杆菌具有优异的光热杀菌效果（808 nm 激光照射），实验结果进一步证明了氙灯照射下良好的光动力学行为。该产品通过结合 PTT/PDT 处理表现出更高的抗菌性能，这表明该工作为有效治疗细菌感染提供了一种新型的双模式光疗纳米剂。
更新日期：2021-09-08
中文翻译：
具有光热-光动力协同抗菌性能的Fe3O4-Au-聚多巴胺杂化微胶囊
与耐药菌相关的传染病日益威胁着公众健康。有效的抗菌纳米平台对于治疗细菌感染特别重要。在这项工作中，开发了一种具有光热 (PTT) 和光动力 (PDT) 抗菌功能的新型磁性 Fe 3 O 4 -Au-PDA 混合微胶囊。首先，通过简单的原位氧化还原-氧化聚合方法获得了具有中空性质的 Fe 3 O 4 @Au/PDA 核/壳微球。然后，它们在酸中蚀刻以改善中空内部和多孔外壳。最后，以四羧基锌酞菁（ZnPc）为光敏剂负载到上述Fe 3 O中4 -Au-PDA 混合微胶囊。由于双模式光热 Au-PDA 杂化壳和 ZnPc 光敏剂，最终的 Fe 3 O 4 -Au-PDA/ZnPc 杂化微胶囊可用作出色的光热/光动力 (PTT/PDT) 协同治疗剂。实验结果表明，Fe 3 O 4 -Au-PDA/ZnPc 微胶囊对大肠杆菌具有优异的光热杀菌效果（808 nm 激光照射），实验结果进一步证明了氙灯照射下良好的光动力学行为。该产品通过结合 PTT/PDT 处理表现出更高的抗菌性能，这表明该工作为有效治疗细菌感染提供了一种新型的双模式光疗纳米剂。
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