Trace analysis and identification of 33 sulfonamides and sulfonamide potentiators in eggs by ultrahigh-performance liquid chromatography coupled with quadrupole-high-field orbitrap high-resolution mass spectrometry,Analytical Methods

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Trace analysis and identification of 33 sulfonamides and sulfonamide potentiators in eggs by ultrahigh-performance liquid chromatography coupled with quadrupole-high-field orbitrap high-resolution mass spectrometry
Analytical Methods ( IF 2.7 ) Pub Date : 2021-08-27 , DOI: 10.1039/d1ay01079d
Suode Cheng ₁ , Zhou Wei ₂ , Xiao Zhiming ₁ , Li Yang ₁ , Fan Xia ₁

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A method was established for the simultaneous trace analysis and identification of 27 sulfonamides and 6 sulfonamide potentiators in eggs by ultrahigh-performance liquid chromatography coupled with quadrupole-high-field orbitrap high-resolution mass spectrometry and multifunction impurity adsorption cleaning. The appropriate extraction, purification, and instrument conditions were optimized. The drugs were extracted by acetonitrile with 1% formic acid and purified with optimized adsorption material based on multifunction impurity adsorption cleaning. The elution was evaporated by nitrogen blowing, dissolved, and then assayed. The limits of detection were 0.01–0.28 μg kg⁻¹ for all drugs, while the recoveries were 82.4–110.6%, the relative standard deviations were 2.5–14.9%, and the linearity of the drugs in the corresponding concentration range was greater than 0.995. The proposed method was successfully applied for the monitoring of sulfonamides and their potentiators in egg samples, whereby 4 sulfonamides and 3 sulfonamide potentiators were detected in 200 egg samples.

中文翻译：

超高效液相色谱-四极杆-高场轨道阱高分辨率质谱法对鸡蛋中33种磺胺类和磺胺类增效剂的痕量分析与鉴定

建立了超高效液相色谱-四极杆-高场轨道阱高分辨率质谱联用多功能杂质吸附清洗同时痕量分析鉴定鸡蛋中27种磺胺类和6种磺胺类增效剂的方法。优化了合适的提取、纯化和仪器条件。药物采用1%甲酸乙腈提取，并采用基于多功能杂质吸附清洗的优化吸附材料进行纯化。通过吹氮蒸发洗脱液，溶解，然后测定。检测限为 0.01–0.28 μg kg ^-1所有药物的回收率为82.4-110.6%，相对标准偏差为2.5-14.9%，相应浓度范围内药物的线性大于0.995。该方法成功应用于鸡蛋样品中磺胺类药物及其增效剂的监测，在200个鸡蛋样品中检测到4种磺胺类药物和3种磺胺类增效剂。

更新日期：2021-09-08

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