FBXO10 prevents chronic unpredictable stress-induced behavioral despair and cognitive impairment through promoting RAGE degradation,CNS Neuroscience & Therapeutics

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FBXO10 prevents chronic unpredictable stress-induced behavioral despair and cognitive impairment through promoting RAGE degradation
CNS Neuroscience & Therapeutics ( IF 4.8 ) Pub Date : 2021-09-07 , DOI: 10.1111/cns.13727
Jiacen Li _{1,

2} , Qingcui Zeng _{2,

3} , Wenjie Su _{1,

2} , Menglong Song _{2,

4} , Min Xie _{1,

2} , Lei Mao _{1,

2}

Affiliation

Depression is one of the leading causes of disability worldwide. The receptor for advanced glycosylation end products (RAGE) is closely related to chronic stress and is a target of F-box protein O10 (FBXO10) which promotes the degradation of RAGE by ubiquitination. Here, we explored the role of FBXO10 and RAGE in chronic unpredictable stress (CUS)-induced behavioral despair, cognitive impairment, neuroinflammation, and the polarization microglia.

中文翻译：

FBXO10 通过促进 RAGE 降解来预防慢性不可预测的压力引起的行为绝望和认知障碍

抑郁症是全球残疾的主要原因之一。晚期糖基化终产物受体 (RAGE) 与慢性应激密切相关，是 F-box 蛋白 O10 (FBXO10) 的靶点，通过泛素化促进 RAGE 的降解。在这里，我们探讨了 FBXO10 和 RAGE 在慢性不可预测压力 (CUS) 诱导的行为绝望、认知障碍、神经炎症和极化小胶质细胞中的作用。

更新日期：2021-09-07

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