The nuclear paraspeckle assembly transcript 1 (NEAT1) is a long non-coding RNA (lncRNA) that is upregulated in a variety of human cancer types. Increasing evidence has shown that the elevation of NEAT1 in cancer cells promotes cell growth, migration, and invasion and inhibits cell apoptosis. It is also known that lncRNAs act as a competing endogenous RNA (ceRNA) by sponging microRNAs (miRNAs) to alter the expression levels of their target genes in the development of cancers. Therefore, it is important to understand the molecular mechanisms underlying this observation. In this review, specific emphasis was placed on NEAT1's role in tumor development. We also summarize and discuss the feedback roles of NEAT1/miRNA/target network in the progression of various cancers. As our understanding of the role of NEAT1 during tumorigenesis improves, its therapeutic potential as a biomarker and/or target for cancer also becomes clearer.

中文翻译：

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NEAT1 作为一种竞争性内源性 RNA 在各种癌症的肿瘤发生中的作用：作用、机制和治疗潜力

核副啄木鸟组装转录本 1 (NEAT1) 是一种长链非编码 RNA (lncRNA)，在多种人类癌症类型中上调。越来越多的证据表明，癌细胞中 NEAT1 的升高可促进细胞生长、迁移和侵袭，并抑制细胞凋亡。众所周知，lncRNAs 作为竞争性内源性 RNA (ceRNA) 通过海绵化 microRNAs (miRNAs) 改变其靶基因在癌症发展中的表达水平。因此，了解这一观察结果背后的分子机制非常重要。在这篇综述中，特别强调了 NEAT1 在肿瘤发展中的作用。我们还总结和讨论了 NEAT1/miRNA/目标网络在各种癌症进展中的反馈作用。随着我们对 NEAT1 在肿瘤发生过程中作用的理解不断提高，