ABSTRACT

Currently, drug delivery systems with low toxicity and high efficacy are urgently needed to suppress cancer cells. Herein, a non-toxic and biocompatible drug carrier (mPEG-luteolin-AuNPs) was prepared, which was characteristic by SEM, FT-IR, XRD, average particle size, zeta potential and UV-Vis spectra, respectively. Considering that the morphology of supramolecular hydrogel was porous which was good for storage of drugs, a stable supramolecular hydrogel self-assembly formed based on mPEG-luteolin-AuNPs and α-cyclodextrin (α-CD) was reported. Then, supramolecular hydrogel loaded doxorubicin hydrochloride (DOX) and sustained DOX release. Meanwhile, in vitro experiments clearly demonstrated that DOX of hydrogel (mPEG-luteolin-AuNPs/DOX) was biologically active, similar to free DOX, but with better cytotoxicity to human glioblastoma cells (U-87 MG) because of its controllable release. Our findings indicated that mPEG-luteolin-AuNPs/DOX might be promising delivery systems for anticancer chemotherapy.

摘要

目前，迫切需要低毒、高效的药物递送系统来抑制癌细胞。在此，制备了一种无毒且生物相容的药物载体（mPEG-木犀草素-AuNPs），分别通过SEM、FT-IR、XRD、平均粒径、zeta电位和UV​​-Vis光谱表征。考虑到超分子水凝胶的形态是多孔的，有利于药物的储存，报道了基于mPEG-木犀草素-AuNPs和α-环糊精（α-CD）形成的稳定的超分子水凝胶自组装体。然后，超分子水凝胶负载盐酸阿霉素 (DOX) 并持续释放 DOX。同时，体外实验清楚地表明水凝胶（mPEG-luteolin-AuNPs/DOX）的DOX具有生物活性，类似于游离DOX，但由于其可控释放，对人胶质母细胞瘤细胞（U-87 MG）具有更好的细胞毒性。我们的研究结果表明，mPEG-木犀草素-AuNPs/DOX 可能是用于抗癌化疗的有前途的递送系统。