3D Printed Multifunctional Ti6Al4V-Based Hybrid Scaffold for the Management of Osteosarcoma,Bioconjugate Chemistry

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3D Printed Multifunctional Ti6Al4V-Based Hybrid Scaffold for the Management of Osteosarcoma
Bioconjugate Chemistry ( IF 4.0 ) Pub Date : 2021-09-07 , DOI: 10.1021/acs.bioconjchem.1c00367
Bianyun Cai _{1,

2} , Leizhen Huang ₁ , Jingcheng Wang ₁ , Dan Sun ₃ , Ce Zhu ₁ , Yong Huang ₁ , Shujun Li ₄ , Zhijun Guo ₅ , Limin Liu ₁ , Ganjun Feng ₁ , Yubao Li ₁ , Li Zhang ₁

Affiliation

Osteosarcoma is a challenging bone disease which is commonly associated with critically sized bone defects and cancer recurrence. Here, we designed and developed a multifunctional, hierarchical structured bone scaffold which can meet the demanding requirements for osteosarcoma management. The 3D printed Ti₆Al₄V scaffold with hydrothermally induced TiO₂/TiP coating can offer a unique photothermal conversion property for in vitro bone cancer ablation. The scaffold is also infused with drug-laden gelatin/hydroxyapatite nanocomposite, which provides the ideal porous structure for cell adhesion/bone ingrowth and promotes bone regeneration. The scaffold has been thoroughly characterized by SEM/EDX, TEM, XPS, XRD, TGA, and UV–vis, and its in vitro bone cancer ablation efficiency has been validated using MG-63 cells. The hybrid scaffold showed excellent biocompatibility, and its osteointegration function has been demonstrated using an animal model.

中文翻译：

3D 打印多功能 Ti6Al4V 混合支架用于治疗骨肉瘤

骨肉瘤是一种具有挑战性的骨病，通常与严重骨缺损和癌症复发有关。在这里，我们设计并开发了一种多功能、分层结构的骨支架，可以满足骨肉瘤治疗的苛刻要求。具有水热诱导TiO ₂ /TiP涂层的3D打印Ti ₆ Al ₄ V支架可以为体外骨癌消融提供独特的光热转换特性。该支架还注入了载药明胶/羟基磷灰石纳米复合材料，为细胞粘附/骨向内生长提供了理想的多孔结构，并促进骨再生。该支架已通过 SEM/EDX、TEM、XPS、XRD、TGA 和 UV-vis 进行了彻底表征，并且其体外骨癌消融效率已使用 MG-63 细胞进行了验证。该混合支架表现出优异的生物相容性，其骨整合功能已通过动物模型得到证实。

更新日期：2021-10-20

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