There is an increase in the incidence of cardiovascular diseases with aging and it is one of the leading causes of death worldwide. The main cardiovascular pathologies include atherosclerosis, myocardial infarction, hypertension and stroke. Chronic inflammation is one of the significant contributors to the age-related vascular diseases. Therefore, it is important to understand the molecular mechanisms of the persistent inflammatory conditions occurring in the blood vessels as well as the signaling pathways involved. Herein, we performed an extant search of literature involving PubMed, ISI, WoS and Scopus databases for retrieving all relevant articles with the most recent findings illustrating the potential role of various inflammatory mediators along with their proposed activated pathways in the pathogenesis and progression of vascular aging. We also highlight the major pathways contributing to age-related vascular disorders. The outlined molecular mechanisms, pathways and mediators of vascular aging represent potential drug targets that can be utilized to inhibit and/or slow the pathogenesis and progression of vascular aging.

中文翻译：

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炎症分子介质和参与血管老化和中风的途径：综合综述。

随着年龄的增长，心血管疾病的发病率有所增加，它是全球死亡的主要原因之一。主要的心血管疾病包括动脉粥样硬化、心肌梗塞、高血压和中风。慢性炎症是导致与年龄相关的血管疾病的重要因素之一。因此，了解血管中发生的持续性炎症状况的分子机制以及所涉及的信号通路非常重要。在此，我们对涉及 PubMed、ISI、WoS 和 Scopus 数据库的现有文献进行了检索，以检索所有相关文章，其中最新发现说明了各种炎症介质的潜在作用以及它们在血管老化的发病机制和进展中提出的激活途径. 我们还强调了导致与年龄相关的血管疾病的主要途径。概述的血管衰老的分子机制、途径和介质代表了潜在的药物靶点，可用于抑制和/或减缓血管衰老的发病机制和进展。