The Effector Domain of the Influenza A Virus Nonstructural Protein NS1 Triggers Host Shutoff by Mediating Inhibition and Global Deregulation of Host Transcription When Associated with Specific Structures in the Nucleus,mBio

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The Effector Domain of the Influenza A Virus Nonstructural Protein NS1 Triggers Host Shutoff by Mediating Inhibition and Global Deregulation of Host Transcription When Associated with Specific Structures in the Nucleus
mBio ( IF 5.1 ) Pub Date : 2021-09-07 , DOI: 10.1128/mbio.02196-21
Wolfgang Nacken _{1,

2} , André Schreiber _{1,

2} , Dörthe Masemann _{1,

2,

3} , Stephan Ludwig _{1,

2,

3}

Affiliation

We investigated the role of IAV nonstructural protein 1 NS1 in host gene shutoff—a central feature of IAV replication. We demonstrate that the effector domain of NS1 alone mediates host gene shutoff by inhibition of host transcription and by deregulation ...

中文翻译：

当与细胞核中的特定结构相关时，甲型流感病毒非结构蛋白 NS1 的效应域通过介导宿主转录的抑制和全局失调来触发宿主关闭

我们研究了 IAV 非结构蛋白 1 NS1 在宿主基因关闭中的作用——这是 IAV 复制的核心特征。我们证明了 NS1 的效应结构域通过抑制宿主转录和放松调节来介导宿主基因关闭...

更新日期：2021-09-12

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