In the present study, we first synthesized pristine ZnO and Sn doped ZnO nanoparticles (NPs) then capped the synthesized NPs by Glutathione at different capping concentrations. The structural, morphological, and optical properties of synthesized NPs was examined by x-ray diffraction (XRD), transmission electron microscopy (TEM), energy dispersive x-ray spectroscopy (EDS), Fourier transform infrared spectroscopy (FTIR), UV–visible, and energy resolved photoluminescence spectroscopy. The XRD analysis confirmed the formation of wurtzite crystal structure of ZnO nano-crystallites while TEM micrographs showed the formation of dendrite nanostructure at higher capping concentration of glutathione in Sn doped ZnO NPS. Strong absorption band around 2525 cm⁻¹ in the IR spectrum indicates the presence of S–H stretching vibration of glutathione which has been disappeared in glutathione capped ZnO NPs. Blue shift in absorption edge was observed in glutathione capped ZnO NPs as compared to uncapped NPs. Moreover, the synthesized NPs showed excellent response against both Gram positive bacteria (Streptococcus sp. & Staphylococcus sp.) and Gram negative (E. coli & Klebsiella sp.) bacteria. Maximum zone of inhibition has been observed with glutathione capped Sn doped ZnO nanostructures. Hence, it can be concluded from the present investigation that the optimization of capping concentration will be very beneficial to exploit Sn doped ZnO semiconductor nanostructures as a coating material for different chemotherapeutic drugs.

在本研究中，我们首先合成了原始的 ZnO 和 Sn 掺杂的 ZnO 纳米粒子 (NPs)，然后用不同封端浓度的谷胱甘肽封端合成的 NPs。通过 X 射线衍射 (XRD)、透射电子显微镜 (TEM)、能量色散 X 射线光谱 (EDS)、傅里叶变换红外光谱 (FTIR)、紫外-可见和能量分辨光致发光光谱。XRD 分析证实了 ZnO 纳米微晶的纤锌矿晶体结构的形成，而 TEM 显微照片显示在 Sn 掺杂的 ZnO NPS 中在较高的谷胱甘肽封端浓度下形成了枝晶纳米结构。2525 cm ^-1附近的强吸收带在红外光谱中表明存在谷胱甘肽的 S-H 伸缩振动，该振动在谷胱甘肽封端的 ZnO NPs 中已消失。与未加帽的 NPs 相比，在谷胱甘肽加帽的 ZnO NPs 中观察到吸收边缘的蓝移。此外，合成的 NPs 对革兰氏阳性菌（链球菌属和葡萄球菌属）和革兰氏阴性菌（大肠杆菌和克雷伯氏菌属）均表现出极好的反应。已观察到谷胱甘肽封端的 Sn 掺杂 ZnO 纳米结构的最大抑菌圈。因此，从目前的研究中可以得出结论，封端浓度的优化将非常有利于利用 Sn 掺杂的 ZnO 半导体纳米结构作为不同化疗药物的涂层材料。