In this study, a highly porous heparin-polyvinylalcohol@TiO₂ nanocomposite (H-PVA@TiO₂) bandage was fabricated by incorporating TiO₂ into H-PVA hydrogel for burn injury. The effects of the H-PVA hydrogel and TiO₂ nanoparticle composition on the functional group and surface properties of the as-prepared bandages were characterized by Fourier transform infrared spectroscopy (FT-IR) and x-ray diffractometry (XRD). The morphology of the H-PVA hydrogel and H-PVA@TiO₂ were evaluated using a scanning electron microscope (SEM) and transmission electron microscope (TEM). A study of the material properties of H-PVA hydrogel has shown that the presence of TiO₂ nanoparticles improves its toughness. Prepared H-PVA@TiO₂ nanoporous dressing has indicated good antimicrobial activity against types of bacteria (Staphylococcus aureus and Escherichia coli) and excellent biocompatibility with human dermal fibroblast cells (HFFF2) suitable for biological applications. Additionally, in vivo experiments using Kunming mice showed it as-prepared H-PVA@TiO₂ nanocomposite dressings improved wound healing and triggered skin cell development alongside collagen growth. Synergistic effects of the H-PVA@TiO₂ nanocomposite hydrogel dressing material through in vivo experiments, such as its excellent hydrophilic design, strong bactericidal activity, biocompatibility and wound healing ability, make it a promising candidate for the treatment of burn injuries.

在这项研究中，通过将 TiO ₂掺入 H-PVA 水凝胶中来制备用于烧伤的高多孔肝素-聚乙烯醇@TiO ₂纳米复合材料（H-PVA@TiO ₂）绷带。通过傅里叶变换红外光谱 (FT-IR) 和 X 射线衍射仪 (XRD) 表征H-PVA 水凝胶和 TiO ₂纳米颗粒组合物对所制备绷带的官能团和表面性质的影响。使用扫描电子显微镜 (SEM) 和透射电子显微镜 (TEM) 评估H-PVA 水凝胶和 H-PVA@TiO _{2 的}形貌。对 H-PVA 水凝胶材料特性的研究表明，TiO ₂的存在纳米粒子提高了它的韧性。制备的H-PVA@TiO ₂纳米多孔敷料对多种细菌（金黄色葡萄球菌和大肠杆菌）具有良好的抗菌活性，并且与适合生物应用的人真皮成纤维细胞（HFFF2）具有良好的生物相容性。此外，使用昆明小鼠的体内实验表明，制备的 H-PVA@TiO ₂纳米复合敷料可改善伤口愈合并在胶原蛋白生长的同时引发皮肤细胞发育。H-PVA@TiO _{2 的}协同效应 纳米复合水凝胶敷料材料通过体内实验，其优异的亲水设计、较强的杀菌活性、生物相容性和伤口愈合能力，使其成为治疗烧伤的有希望的候选材料。