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Photo-Promoted Decarboxylative Alkylation of α,β-Unsaturated Carboxylic Acids with ICH2CN for the Synthesis of β,γ-Unsaturated Nitriles
Organic Letters ( IF 4.9 ) Pub Date : 2021-09-07 , DOI: 10.1021/acs.orglett.1c02585 Chunxiang Pan 1 , Chunhui Yang 1 , Kangkui Li 1 , Keyang Zhang 1 , Yuanbin Zhu 2 , Shiyuan Wu 2 , Yongyun Zhou 3 , Baomin Fan 3
Organic Letters ( IF 4.9 ) Pub Date : 2021-09-07 , DOI: 10.1021/acs.orglett.1c02585 Chunxiang Pan 1 , Chunhui Yang 1 , Kangkui Li 1 , Keyang Zhang 1 , Yuanbin Zhu 2 , Shiyuan Wu 2 , Yongyun Zhou 3 , Baomin Fan 3
Affiliation
An efficient, catalyst/photocatalyst-free, and cost-effective methodology for the decarboxylative alkylation of α,β-unsaturated carboxylic acids to synthesize β,γ-unsaturated nitriles has been developed. The reaction proceeded in an environmentally benign atmosphere of blue light-emitting diode irradiation with K2CO3 and water at room temperature. The methodology worked for a wide range of substrates (22 examples) with up to 83% yield. The protocol is also compatible for gram-scale synthesis.
中文翻译:
α,β-不饱和羧酸与 ICH2CN 光促进脱羧烷基化合成 β,γ-不饱和腈
已开发出一种高效、无催化剂/光催化剂且具有成本效益的方法,用于α , β -不饱和羧酸的脱羧烷基化以合成β , γ -不饱和腈。该反应在室温下用 K 2 CO 3和水在蓝光发光二极管照射的环境友好气氛中进行。该方法适用于多种基材(22 个示例),产率高达 83%。该协议也适用于克级合成。
更新日期:2021-09-17
中文翻译:
α,β-不饱和羧酸与 ICH2CN 光促进脱羧烷基化合成 β,γ-不饱和腈
已开发出一种高效、无催化剂/光催化剂且具有成本效益的方法,用于α , β -不饱和羧酸的脱羧烷基化以合成β , γ -不饱和腈。该反应在室温下用 K 2 CO 3和水在蓝光发光二极管照射的环境友好气氛中进行。该方法适用于多种基材(22 个示例),产率高达 83%。该协议也适用于克级合成。