Recently, the development of biosafe nanocomposites with integrated diagnosis and therapeutic modality is received great attention in anti-cancer drug delivery. In this sturdy, we developed a multifunctional PION@PDA-PEG nanocomposite that combines the functions of magnetic resonance (MR) imaging, photothermal therapy (PTT) and chemotherapy into one single nanoprobe. The spherical and uniform-sized porous iron oxide nanoparticles (PION) were synthesized via a simple solvothermal method. Subsequently, a near-infrared light (NIR) sensitive polydopamine (PDA) shell was directly coated on the surface of PIONs to form monodisperse and biosafe core-shell nanocomposites, Thereafter, the surface of nanocomposites was further modified with polyethylene glycol (PEG) to prolong their blood circulation lifetime. The prepared PION@PDA-PEG showed excellent biocompatibility and promising MR imaging contrast agent capability. Furthermore, the porous structure of PION and the abundant functional groups of PDA shell permitted the remarkable drug loading capacity of more than 24.1 wt%. In addition, the synergistic photothermal- chemotherapy exhibited obvious enhanced anti-tumor effect in in-vitro cell experiment. These results suggest that the developed PION@PDA-PEG nanocomposite can be utilized as an efficient drug nanocarrier for biomedical applications including MR imaging and photothermal-chemotherapy.

最近，具有集成诊断和治疗方式的生物安全纳米复合材料的开发在抗癌药物递送中受到了极大的关注。为此，我们开发了一种多功能 PION@PDA-PEG 纳米复合材料，将磁共振 (MR) 成像、光热疗法 (PTT) 和化学疗法的功能结合到一个纳米探针中。通过简单的溶剂热法合成了球形且尺寸均匀的多孔氧化铁纳米粒子 (PION)。随后，将近红外光 (NIR) 敏感的聚多巴胺 (PDA) 壳直接包覆在 PIONs 表面形成单分散和生物安全的核壳纳米复合材料，然后用聚乙二醇 (PEG) 进一步改性纳米复合材料的表面，延长血液循环寿命。制备的 PION@PDA-PEG 显示出优异的生物相容性和有前途的 MR 成像造影剂能力。此外，PION 的多孔结构和 PDA 壳的丰富官能团允许超过 24.1 wt% 的显着载药量。此外，协同光热化疗在抗肿瘤作用方面表现出明显增强。体外细胞实验。这些结果表明，所开发的 PION@PDA-PEG 纳米复合材料可用作有效的药物纳米载体，用于包括 MR 成像和光热化疗在内的生物医学应用。