Glucocorticoid resistance often dims glucocorticoid’s therapeutic efficacy in sepsis. However, the mechanism is incompletely understood. In this issue, Vandewalle et al. (2021) demonstrate that glucocorticoid resistance leads to hyperlactatemia and that this combination facilitates lethal sepsis. This insight gives important clarity to the pathophysiology of sepsis, while further suggesting therapeutic avenues for its treatment.

中文翻译：

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糖皮质激素抵抗和高乳酸血症：恶化败血症的标签团队

糖皮质激素抵抗常常使糖皮质激素在脓毒症中的治疗效果变暗。然而，该机制尚不完全清楚。在这个问题上，Vandewalle 等人。(2021) 证明糖皮质激素抵抗会导致高乳酸血症，并且这种组合会促进致命的败血症。这一见解为脓毒症的病理生理学提供了重要的清晰度，同时进一步提出了治疗途径。