Supporting the notion that cell lineage is a key determinant of cancer cell metabolism, Jun et al. (2021) identify a selective requirement for pyruvate dehydrogenase (PDH) activity in T cells and T cell leukemia, but not hematopoietic stem cells (HSCs) or myeloid leukemia, in this issue of Cell Metabolism.

中文翻译：

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T细胞严重依赖丙酮酸氧化

Jun等人支持细胞谱系是癌细胞代谢的关键决定因素的观点。(2021) 在本期《细胞代谢》中确定了对 T 细胞和 T 细胞白血病中丙酮酸脱氢酶 (PDH) 活性的选择性要求，而不是造血干细胞 (HSC) 或髓性白血病。