Electromembrane extraction (EME), involving the migration of charged analytes across a supported liquid membrane (SLM) with an external power supply, is a promising sample preparation method in analytical chemistry. However, the presence of boundary double layers at the SLM/solution interfaces often restricts extraction efficiency. To avoid this, the current work proposed an ultrasound-assisted EME (UA-EME) method based on a novel type of supported semi-liquid membrane (SsLM). The characterizations showed that the SsLM was stable under ultrasound conditions. Ultrasound was found to reduce the boundary double layers and thus increase the mass transfer. Major operational parameters in UA-EME including ultrasound power density, temperature, applied voltage and extraction time were optimized with haloperidol, fluoxetine, and sertraline as model analytes. Under the optimal conditions, extraction recoveries of model analytes in water samples were in the range of 66.8%–91.6%. When this UA-EME method was coupled with LC-MS/MS for detection of the target analytes in human urine samples, the linear range of the analytical method was 10–1000 ng mL⁻¹, with R² > 0.997 for all analytes. The limits of detection (LOD) and limits of quantification (LOQ) were in the range of 1.7–2.1 ng mL⁻¹ and 5.7–6.7 ng mL⁻¹, respectively. The UA-EME expands the application field of ultrasound chemistry and will be very important in development of stable and fast sample preparation systems in the future.

电膜萃取 (EME) 涉及带电分析物在外部电源的情况下穿过支撑液膜 (SLM) 的迁移，是分析化学中一种很有前途的样品制备方法。然而，SLM/解决方案界面处边界双层的存在通常会限制提取效率。为避免这种情况，目前的工作提出了一种基于新型支撑半液膜 (SsLM) 的超声辅助 EME (UA-EME) 方法。表征表明，SsLM 在超声条件下是稳定的。发现超声波可以减少边界双层，从而增加传质。UA-EME 的主要操作参数，包括超声功率密度、温度、施加电压和提取时间，均使用氟哌啶醇、氟西汀、和舍曲林作为模型分析物。在最佳条件下，水样中模型分析物的提取回收率在66.8%~91.6%之间。当这种 UA-EME 方法与 LC-MS/MS 结合用于检测人尿样品中的目标分析物时，该分析方法的线性范围为 10–1000 ng mL^-1， 对于所有分析物，R ² > 0.997。检测限 (LOD) 和定量限 (LOQ) 分别在 1.7-2.1 ng mL ^-1和 5.7-6.7 ng mL ^-1的范围内。UA-EME拓展了超声化学的应用领域，对未来稳定快速的样品制备系统的开发具有重要意义。