Reactivity Analysis of New Multivalent Electrophilic Probes for Affinity Labeling of Carbohydrate Binding Proteins,ChemBioChem

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Reactivity Analysis of New Multivalent Electrophilic Probes for Affinity Labeling of Carbohydrate Binding Proteins
ChemBioChem ( IF 2.6 ) Pub Date : 2021-09-06 , DOI: 10.1002/cbic.202100388
Shione Kamoshita ₁ , Saho Matsui ₁ , Nanako Suto ₁ , Kaori Sakurai ₁

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A set of gold nanoparticle-based affinity labeling probes multivalently presenting different electrophilic groups and a carbohydrate ligand was synthesized to evaluate their reactivity against lectins. The p- and m-isomers of arylsulfonyl fluoride groups together are promising alternatives to photoreactive groups as protein-reactive affinity labels for target identification studies.

中文翻译：

用于碳水化合物结合蛋白亲和标记的新型多价亲电探针的反应性分析

合成了一组基于金纳米颗粒的亲和标记探针，该探针多价呈现不同的亲电基团和碳水化合物配体，以评估它们对凝集素的反应性。芳基磺酰氟基团的p和m异构体一起是光反应性基团的有希望的替代品，可作为用于目标识别研究的蛋白质反应性亲和标记。

更新日期：2021-09-06

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