ABSTRACT

Traumatic brain injury (TBI) involves structural damage to the brain regions causing death or disability in patients with lifelong sufferings. Accidental injuries to the brain, besides structural damage, if any, cause activation of various deleterious pathways leading to subsequent neuronal death and permanent dysfunction. However, immediate medical management/treatments could reduce the chances of disability and suffering to the patients. The objective of the current review is to review triggered molecular pathways following TBI and discuss possible targets that could restore brain functions. Understanding the pathologic process is always useful to device novel treatment strategies and may rescue the patient with TBI from death or associated co-morbidities. The current review significantly contributes to improve our understanding about the molecular pathways and neuronal death following TBI and helps us to provide possible targets that could be useful in the management/treatment of TBI.

摘要

创伤性脑损伤 (TBI) 涉及大脑区域的结构性损伤，导致终生受苦的患者死亡或残疾。对大脑的意外伤害，除了结构性损伤，如果有的话，会导致各种有害途径的激活，导致随后的神经元死亡和永久性功能障碍。然而，即时的医疗管理/治疗可以减少患者残疾和痛苦的机会。当前审查的目的是审查 TBI 后触发的分子途径，并讨论可以恢复大脑功能的可能目标。了解病理过程对于制定新的治疗策略总是有用的，并且可以使 TBI 患者免于死亡或相关的合并症。