ABSTRACT

Mild traumatic brain injuries (mTBI) are associated with functional network connectivity alterations throughout recovery. Yet, little is known about the adaptive or maladaptive nature of post-mTBI connectivity and which networks are predisposed to altered function and adaptation. The objective of this review was to determine functional connectivity changes post-mTBI and to determine the adaptive or maladaptive nature of connectivity through direct comparisons of connectivity and behavioral data. Literature was systematically searched and appraised for methodological quality. A total of 16 articles were included for review. There was conflicting evidence of post-mTBI connectivity responses as decreased connectivity was noted in 4 articles, 6 articles reported increased connectivity, 5 reported a mixture of increased and decreased connectivity, while 1 found no differences in connectivity. Supporting evidence for adaptive post-mTBI increases in connectivity were found, particularly in the frontoparietal, cerebellar, and default mode networks. Although initial results are promising, continued longitudinal research that systematically controls for confounding variables and that standardizes methodologies is warranted to adequately understand the neurophysiological recovery trajectory of mTBI.

摘要

轻度创伤性脑损伤 (mTBI) 与恢复过程中功能网络连接的改变有关。然而，人们对 mTBI 后连接的适应性或适应不良性质以及哪些网络容易发生功能和适应改变知之甚少。本次审查的目的是确定 mTBI 后功能连接的变化，并通过直接比较连接和行为数据来确定连接的适应性或适应不良性质。对文献进行了系统检索和方法质量评价。共纳入16篇文章供审查。mTBI 后连接性反应的证据相互矛盾，因为 4 篇文章指出连接性下降，6 篇文章报告连接性增加，5 篇文章报告连接性增加和减少的混合，而 1 发现连接性没有差异。发现了支持 mTBI 后适应性连接性增加的证据，特别是在额顶叶、小脑和默认模式网络中。尽管初步结果令人鼓舞，但仍需要持续的纵向研究来系统地控制混杂变量并标准化方法，以充分了解 mTBI 的神经生理学恢复轨迹。