A novel series of 3,5-disubstituted isoxazoles bearing kojic acid moiety were synthesized via Cu(I)-catalyzed 1,3-dipolar cycloaddition reaction of terminal alkynes with nitrile oxide formed in situ from the corresponding hydroximoyl chloride. Structures of the synthesized compounds were characterized using spectroscopic analysis data. Antimicrobial activity of the isoxazole conjugates was determined as MIC values by broth microdilution method against different bacteria: Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Salmonella typhi, and fungi Candida kefyr. The obtained results revealed notable antibacterial and antifungal activities of the compounds.

一系列带有曲酸部分的新型 3,5-二取代异恶唑是通过Cu(I) 催化的末端炔烃与相应的羟肟酰氯原位形成的氧化腈的 1,3-偶极环加成反应合成的。使用光谱分析数据表征合成化合物的结构。异恶唑偶联物的抗菌活性通过肉汤微量稀释法对不同细菌的 MIC 值确定：金黄色葡萄球菌、枯草芽孢杆菌、大肠杆菌、伤寒沙门氏菌和真菌念珠菌. 所得结果表明化合物具有显着的抗菌和抗真菌活性。