Microchimica Acta ( IF 5.3 ) Pub Date : 2021-09-06 , DOI: 10.1007/s00604-021-04969-w Sijie Cheng 1 , Junqiu Zhang 2 , Yaoming Liu 1 , Yingte Wang 1 , Yanteng Xiao 1 , Yong Zhang 1
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Water soluble N, S-doped carbon dots (N, S-CDs) with orange emission were synthesized from basic fuchsin and sulfosalicylic acid by the typical hydrothermal route. Based on the inner filter effect (IFE), the prepared N, S-CDs can be innovatively developed as an effective “signal-off” multifunctional sensing platform for sensitive determination of tetracycline antibiotics (for example, chlortetracycline (CTC)) and quercetin. The proposed sensor was utilized to realize the determination of CTC in water and milk samples and quercetin in beer sample (λex = 375 nm, λem = 605 nm) with satisfactory recoveries and relative standard deviations (RSD). The linear range and detection limit (LOD) of CTC is 1.24–165 μM and 32.36 nM, respectively. For quercetin, the linear ranges are 0.98–34 μM and 34–165 μΜ, and the LOD is 6.87 nM (3σ/m). By virtue of the good biocompatibility and long-wavelength emission, N, S-CDs were also used in the imaging of oocystis cells and yeast cells, which demonstrated promising applicability for bio-imaging and sensing.
Graphical abstract
中文翻译：
一步合成具有橙色发射的 N、S 掺杂碳点及其在四环素抗生素、槲皮素传感和细胞成像中的应用
以碱性品红和磺基水杨酸为原料，采用典型的水热法合成了具有橙色发射的水溶性氮、硫掺杂碳点（N，S-CDs）。基于内滤效应（IFE），所制备的N，S-CDs可以创新地开发为一种有效的“信号关闭”多功能传感平台，用于灵敏测定四环素类抗生素（例如金霉素（CTC））和槲皮素。该传感器用于实现水和牛奶样品中 CTC 和啤酒样品中槲皮素的测定（λex = 375 nm，λem = 605 nm），具有令人满意的回收率和相对标准偏差 (RSD)。CTC 的线性范围和检测限 (LOD) 分别为 1.24–165 μM 和 32.36 nM。对于槲皮素，线性范围为 0.98–34 μM 和 34–165 μM，LOD 为 6.87 nM (3σ/m)。
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