Depyrogenation using plasmas: A novel approach for endotoxin deactivation using a dielectric barrier discharge at atmospheric pressure,Plasma Processes and Polymers

当前位置： X-MOL 学术 › Plasma Processes Polym. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Depyrogenation using plasmas: A novel approach for endotoxin deactivation using a dielectric barrier discharge at atmospheric pressure
Plasma Processes and Polymers ( IF 2.9 ) Pub Date : 2021-09-07 , DOI: 10.1002/ppap.202100089
Naman Bhatt ₁ , Justin Brier-Jones ₂ , Duncan Trosan ₁ , Cade Brinkley ₁ , Joshua Pecoraro ₁ , Jann Smallwood ₃ , Andrew Crofton _{2,

4} , Samuel Hudson _{2,

5} , Wolff Kirsch _{2,

3,

6} , Katharina Stapelmann ₁ , Steven Shannon ₁

Affiliation

Developing a low-cost depyrogenation process is vital in extending the medical applicability of polymers that can be used in medicine. We present an overview of the plasma-based depyrogenation literature and address the need to develop a nonthermal plasma-based depyrogenation process for delicate materials such as chitosan. We present a low-cost plasma apparatus to treat chitosan powder in hermetically sealed bags. We decouple the experiments into two parts: depyrogenation experiments for dried standard endotoxin on glass slides and analysis of chitosan modifications through Fourier-transform infrared spectroscopy. We demonstrate depyrogenation efficacy with up to a 4-log reduction in endotoxin levels and discuss minor changes observed in plasma-treated chitosan.

中文翻译：

使用等离子体去热原：在大气压下使用介质阻挡放电来灭活内毒素的新方法

开发低成本的去热原工艺对于扩展可用于医学的聚合物的医学适用性至关重要。我们概述了基于等离子体的去热原文献，并解决了为壳聚糖等精细材料开发基于非热等离子体的去热原工艺的需求。我们提出了一种低成本的等离子体设备来处理密封袋中的壳聚糖粉末。我们将实验分为两部分：载玻片上干燥标准内毒素的去热原实验和通过傅里叶变换红外光谱分析壳聚糖修饰。我们证明了去热原功效，内毒素水平降低了 4 个对数级，并讨论了在血浆处理的壳聚糖中观察到的微小变化。

更新日期：2021-11-04

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11