Exposure to polychlorinated biphenyls (PCBs) is implicated in adverse neurotoxic outcomes. However, the impact of PCBs on the adolescent nervous system has received inadequate attention. We conducted a comprehensive review to identify studies of neurotoxic outcomes following PCB exposure during the adolescent period in rodents. Only four papers were found to meet all inclusion criteria. PCB exposure in adolescent rats caused disruptions in the main functions of the prefrontal cortex, resulting in cognitive deficits. This comprehensive review demonstrates that more research is needed to characterize how PCB exposure adversely affects the adolescent nervous system.

中文翻译：

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青春期多氯联苯暴露对神经系统的影响：综合评价

接触多氯联苯 (PCB) 与不良神经毒性结果有关。然而，PCBs对青少年神经系统的影响却没有引起足够的重视。我们进行了一项全面审查，以确定啮齿动物青春期暴露于 PCB 后的神经毒性结果的研究。仅发现四篇论文符合所有纳入标准。青春期大鼠暴露于 PCB 会导致前额叶皮层的主要功能中断，从而导致认知缺陷。这项综合审查表明，需要更多的研究来表征 PCB 暴露如何对青少年神经系统产生不利影响。