ABSTRACT

It would be quite convenient if every protein had one distinct function, one distinct role in just a single cellular process. In the field of macroautophagy/autophagy, however, we are increasingly finding that this is not the case; several autophagy proteins have two or more roles within the process of autophagy and many even “moonlight” as functional members of entirely different cellular processes. This is perhaps best exemplified by the Atg8-family proteins. These dynamic proteins have already been reported to serve several functions both within autophagy (membrane tethering, membrane fusion, binding to cargo receptors, binding to autophagy machinery) and beyond (LC3-associated phagocytosis, formation of EDEMosomes, immune signaling) but as Maruyama and colleagues suggest in their recent report, this list of functions may not yet be complete.

摘要

如果每一种蛋白质都具有一种独特的功能，在一个单一的细胞过程中具有一种独特的作用，那将是非常方便的。然而，在巨自噬/自噬领域，我们越来越多地发现情况并非如此。几种自噬蛋白在自噬过程中具有两个或多个作用，许多甚至“月光”作为完全不同细胞过程的功能成员。这也许是 Atg8 家族蛋白的最佳例证。据报道，这些动态蛋白在自噬（膜束缚、膜融合、与货物受体结合、与自噬机制结合）和超越（LC3 相关的吞噬作用、EDEMosomes 的形成、免疫信号传导）内发挥多种功能，但如 Maruyama 和同事们在他们最近的报告中建议，这个功能列表可能还不完整。