Gut microbiota is the natural residents of the intestinal ecosystem which display multiple functions that provide beneficial effects on host physiology. Disturbances in gut microbiota in weaning stress are regulated by the immune system and oxidative stress-related protein pathways. Weaning stress also alters gut microbiota response, limits digestibility, and influences animal productive performance through the production of inflammatory molecules. Heat shock proteins are the molecular chaperones that perform array functions from physiological to pathological point of view and remodeling cellular stress response. As it is involved in the defense mechanism, polyphenols ensure cellular tolerance against enormous stimuli. Polyphenols are nature-blessed compounds that show their existence in plenty of amounts. Due to their wider availability and popularity, they can exert strong immunomodulatory, antioxidative, and anti-inflammatory activities. Their promising health-promoting effects have been demonstrated in different cellular and animal studies. Dietary interventions with polyphenols may alter the gut microbiome response and attenuate the weaning stress related to inflammation. Further, polyphenols elicit health-favored effects through ameliorating inflammatory processes to improve digestibility and thereby exert a protective effect on animal production. Here, in this article, we will expand the role of dietary polyphenol intervention strategies in weaning stress which perturbs gut microbiota function and also paid emphasis to heat shock proteins in gut health. This review article gives new direction to the feed industry to formulate diet containing polyphenols which would have a significant impact on animal health.

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多酚在热休克蛋白和肠道菌群在断奶应激中的调节作用

肠道微生物群是肠道生态系统的自然居民，具有多种功能，对宿主生理学产生有益影响。断奶应激中肠道微生物群的紊乱受免疫系统和氧化应激相关蛋白通路的调节。断奶压力还会改变肠道微生物群反应，限制消化率，并通过产生炎症分子影响动物的生产性能。热休克蛋白是从生理到病理角度执行阵列功能并重塑细胞应激反应的分子伴侣。由于涉及防御机制，多酚可确保细胞对巨大刺激的耐受性。多酚是大自然赐予的化合物，它们大量存在。由于它们更广泛的可用性和受欢迎程度，它们可以发挥强大的免疫调节、抗氧化和抗炎活性。不同的细胞和动物研究已经证明了它们有希望的健康促进作用。多酚的饮食干预可能会改变肠道微生物组的反应并减轻与炎症相关的断奶压力。此外，多酚通过改善炎症过程以提高消化率，从而对动物生产产生保护作用，从而产生有益于健康的作用。在这里，在本文中，我们将扩展膳食多酚干预策略在断奶应激中的作用，这种应激会扰乱肠道微生物群的功能，并强调热休克蛋白在肠道健康中的作用。