We demonstrate here that DNA-binding small molecules stabilize hairpin structures formed in short tandem repeat sequences, leading to efficient contractions of repeats during in vitro DNA synthesis. Repeat contraction by synthetic small molecules shows a repeat-number and sequence selective manner.

中文翻译：

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重复结合分子在体外 DNA 合成过程中的短串联重复收缩

我们在此证明 DNA 结合小分子可以稳定短串联重复序列中形成的发夹结构，从而导致体外 DNA 合成过程中重复的有效收缩。合成小分子的重复收缩显示出重复数量和序列选择性方式。