Construction of a survival prediction model for high-and low -grade UTUC after tumor resection based on “SEER database”: a multicenter study,BMC Cancer

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Construction of a survival prediction model for high-and low -grade UTUC after tumor resection based on “SEER database”: a multicenter study
BMC Cancer ( IF 3.4 ) Pub Date : 2021-09-07 , DOI: 10.1186/s12885-021-08742-3
Mengmeng Wang ₁ , Xin Ren ₁ , Ge Wang ₁ , Xiaomin Sun ₁ , Shifeng Tang ₂ , Baogang Zhang ₃ , Xiaoming Xing ₄ , Wenfeng Zhang ₁ , Guojun Gao ₅ , Jing Du ₆ , Shukun Zhang ₇ , Lijuan Liu ₂ , Xia Zheng ₂ , Zhenkun Zhang ₈ , Changgang Sun _{2,

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Affiliation

There are differences in survival between high-and low-grade Upper Tract Urothelial Carcinoma (UTUC). Our study aimed to develop a nomogram to predict overall survival (OS) of patients with high- and low-grade UTUC after tumor resection, and to explore the difference between high- and low-grade patients. Patients confirmed to have UTUC between 2004 and 2015 were selected from the Surveillance, Epidemiology and End Results (SEER) database. The UTUCs were identified and classified as high- and low-grade, and 1-, 3- and 5-year nomograms were established. The nomogram was then validated using the Chinese multicenter dataset (patients diagnosed in Shandong, China between January 2010 and October 2020). In the high-grade UTUC patients, nine important factors related to survival after tumor resection were identified to construct nomogram. The C index of training dataset was 0.740 (95% confidence interval [CI]: 0.727–0.754), showing good calibration. The C index of internal validation dataset was 0.729(95% CI:0.707–0.750). On the other hand, Two independent predictors were identified to construct nomogram of low-grade UTUC. The C index was 0.714 (95% CI: 0.671–0.758) for the training set,0.731(95% CI:0.670–0.791) for the internal validation dataset. Encouragingly, the nomogram was clinically useful and had a good discriminative ability to identify patients at high risk. We constructed a nomogram and a corresponding risk classification system predicting the OS of patients with an initial diagnosis of high-and low-grade UTUC.

更新日期：2021-09-07

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