Drug-resistant temporal lobe epilepsy (TLE) is typically associated with hippocampal pathology. However, widespread network alterations are increasingly recognized and suggested to perturb cognitive function in multiple domains. Here we tested (1) whether TLE shows atypical cortical hierarchical organization, differentiating sensory and higher order systems; and (2) whether atypical hierarchy predicts cognitive impairment.

中文翻译：

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非典型功能连接组层次结构影响颞叶癫痫的认知

耐药性颞叶癫痫 (TLE) 通常与海马病理相关。然而，广泛的网络改变越来越多地被认可并建议扰乱多个领域的认知功能。在这里，我们测试了（1）TLE 是否表现出非典型的皮质分层组织，区分感觉系统和高阶系统；(2) 非典型等级是否能预测认知障碍。